LEADER 04316nam 2201069z- 450 001 9910367740903321 005 20231214133621.0 010 $a3-03921-689-9 035 $a(CKB)4100000010106308 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/45547 035 $a(EXLCZ)994100000010106308 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDual Specificity Phosphatases: From Molecular Mechanisms to Biological Function 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (240 p.) 311 $a3-03921-688-0 330 $aDual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease. 517 $aDual Specificity Phosphatases 610 $ahematopoietic cells 610 $aDEPArray 610 $aneuroblastoma 610 $aliver steatosis 610 $aMAPK phosphatase 610 $aDUSP-4 610 $agranule neurons 610 $aneuronal differentiation 610 $aDUSP10 610 $acytokines 610 $aMAPKs 610 $asingle cell analysis 610 $amacrophage 610 $aasthma 610 $aE. coli infection 610 $aMAPK 610 $aCpp1 610 $anucleotide receptors 610 $aatypical DUSP 610 $aRSV 610 $aPmp1 610 $acannabinoids 610 $aastrocytes 610 $asepsis 610 $ainfluenza 610 $asignaling 610 $atriple-negative breast cancer (TNBC) 610 $adifferentiation 610 $aHDAC6 (histone deacetylase isoform 6) 610 $aatypical dual-specificity phosphatases 610 $amicrotubules 610 $arespiratory viruses 610 $aMK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein) 610 $adual-specificity phosphatase 610 $aMsg5 610 $aTLR signaling 610 $amitogen-activated protein kinase 610 $afungal MKPs 610 $amacrophages 610 $aMAP Kinase Phosphatase-2 610 $ainflammation 610 $aSdp1 610 $acirculating tumor cells (CTCs) 610 $aMAP kinases 610 $aMAP kinase phosphatases 610 $aP2X7 610 $aproliferation 610 $aBDNF 610 $aP2Y13 610 $aT cell 610 $ahypertriglyceridemia 610 $aintegrated omics analysis 610 $apost-translational modification 610 $arhinovirus 610 $aprotein stability 610 $aubiquitination 610 $adual-specificity phosphatases 610 $aMkp-1 610 $acancer 610 $abrain metastasis 610 $aHER2 610 $aCOPD 610 $apseudophosphatase 700 $aPulido$b Rafael$4auth$01323466 702 $aLang$b Roland$4auth 906 $aBOOK 912 $a9910367740903321 996 $aDual Specificity Phosphatases: From Molecular Mechanisms to Biological Function$93035585 997 $aUNINA