LEADER 04280nam 2201201z- 450 001 9910639988903321 005 20231214133540.0 010 $a3-0365-6138-2 035 $a(CKB)5470000001633465 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/95845 035 $a(EXLCZ)995470000001633465 100 $a20202301d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNatural Products and Disease Prevention, Relief and Treatment 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 electronic resource (234 p.) 311 $a3-0365-6137-4 330 $aThe consumption of fruits, vegetables, herbs, spices, etc., is thought to be associated with reduced risk for many human diseases, including cancers. Recently, significant advances have been made in evaluating the efficacy of natural products (compounds from natural sources) against human diseases. The purpose of this Special Issue, ?Natural Products and Disease Prevention, Relief and Treatment", was to collect manuscripts concerning natural products for treating human diseases. Consequently, we have collected several high-quality manuscripts that focus on the molecular mechanisms of natural products, including their anti-inflammatory, antioxidative, neuroprotective, cardioprotective, antifibrotic, and anticancer effects, as well as other health beneficial effects across a wide range of human diseases. Overall, this Special Issue is an excellent source for information on promising natural products for future preclinical and clinical research into multiple diseases. 606 $aMedicine$2bicssc 606 $aPharmacology$2bicssc 610 $aRubi Fructus 610 $aRubus coreanus 610 $alipopolysaccharide 610 $amacrophage 610 $aER stress 610 $acalcium 610 $achop 610 $aSTAT 610 $acytokine 610 $anitric oxide 610 $a?-glucan 610 $aanticancer activity 610 $aantioxidant 610 $aanti-inflammatory 610 $acyclooxygenase 610 $alipoxygenase 610 $acauliflower mushroom 610 $abreast cancer 610 $aSpirulina 610 $atocotrienol 610 $aimmunomodulatory 610 $asynergistic 610 $ametastasis 610 $aYG-1 extract 610 $abronchodilation 610 $afine particulate matter (PM2.5) 610 $aacute lung injury 610 $aairway inflammation 610 $apancreatic cancer 610 $anatural product 610 $atraditional medicine 610 $aapoptosis 610 $aangiogenesis 610 $adrug resistance 610 $ainflammation 610 $ainterleukin-6 610 $asepsis 610 $aDracocephalum moldavica 610 $aNASH 610 $alactoferrin 610 $afibrosis 610 $ahepatocarcinogenesis 610 $aconnexin 610 $abrown algae 610 $aSargassum plagiophyllum 610 $aconstipation 610 $agastrointestinal transit 610 $agut microbiota 610 $atransepithelial transport 610 $aglaucoma 610 $aherbs 610 $aretinal ganglion cells 610 $aintraocular pressure 610 $aSLC22A12 610 $aquercetin 610 $afisetin 610 $auricosuric activity 610 $aanti-hyperuricemia 610 $afunctional food 610 $atransporter 610 $auric acid 610 $ahealth promotion 610 $arooibos tea 610 $adoxorubicin 610 $amokko lactone 610 $aheart 610 $aMokko lactone 610 $aDracocephalum moldavica ethanol extract 610 $aSparassis crispa 610 $afisetin and quercetin 610 $aSargassum plagiophyllum extract 615 7$aMedicine 615 7$aPharmacology 700 $aIslam$b Md Soriful$4edt$01309561 702 $aIslam$b Md Soriful$4oth 906 $aBOOK 912 $a9910639988903321 996 $aNatural Products and Disease Prevention, Relief and Treatment$93029389 997 $aUNINA LEADER 04439nam 2201117z- 450 001 9910367740903321 005 20210211 010 $a3-03921-689-9 035 $a(CKB)4100000010106308 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/45547 035 $a(oapen)doab45547 035 $a(EXLCZ)994100000010106308 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDual Specificity Phosphatases: From Molecular Mechanisms to Biological Function 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 online resource (240 p.) 311 08$a3-03921-688-0 330 $aDual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease. 517 $aDual Specificity Phosphatases 606 $aBiology, life sciences$2bicssc 610 $aasthma 610 $aastrocytes 610 $aatypical dual-specificity phosphatases 610 $aatypical DUSP 610 $aBDNF 610 $abrain metastasis 610 $acancer 610 $acannabinoids 610 $acirculating tumor cells (CTCs) 610 $aCOPD 610 $aCpp1 610 $acytokines 610 $aDEPArray 610 $adifferentiation 610 $adual-specificity phosphatase 610 $adual-specificity phosphatases 610 $aDUSP-4 610 $aDUSP10 610 $aE. coli infection 610 $afungal MKPs 610 $agranule neurons 610 $aHDAC6 (histone deacetylase isoform 6) 610 $ahematopoietic cells 610 $aHER2 610 $ahypertriglyceridemia 610 $ainflammation 610 $ainfluenza 610 $aintegrated omics analysis 610 $aliver steatosis 610 $amacrophage 610 $amacrophages 610 $aMAP Kinase Phosphatase-2 610 $aMAP kinase phosphatases 610 $aMAP kinases 610 $aMAPK 610 $aMAPK phosphatase 610 $aMAPKs 610 $amicrotubules 610 $amitogen-activated protein kinase 610 $aMK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein) 610 $aMkp-1 610 $aMsg5 610 $an/a 610 $aneuroblastoma 610 $aneuronal differentiation 610 $anucleotide receptors 610 $aP2X7 610 $aP2Y13 610 $aPmp1 610 $apost-translational modification 610 $aproliferation 610 $aprotein stability 610 $apseudophosphatase 610 $arespiratory viruses 610 $arhinovirus 610 $aRSV 610 $aSdp1 610 $asepsis 610 $asignaling 610 $asingle cell analysis 610 $aT cell 610 $aTLR signaling 610 $atriple-negative breast cancer (TNBC) 610 $aubiquitination 615 7$aBiology, life sciences 700 $aPulido$b Rafael$4auth$01323466 702 $aLang$b Roland$4auth 906 $aBOOK 912 $a9910367740903321 996 $aDual Specificity Phosphatases: From Molecular Mechanisms to Biological Function$93035585 997 $aUNINA