LEADER 03391nam 2200649 a 450 001 9910830680503321 005 20230721005106.0 010 $a1-118-21037-9 010 $a1-282-13705-0 010 $a9786612137051 010 $a0-470-41379-4 010 $a0-470-41378-6 035 $a(CKB)1000000000719525 035 $a(EBL)427695 035 $a(OCoLC)476270402 035 $a(SSID)ssj0000147485 035 $a(PQKBManifestationID)11149293 035 $a(PQKBTitleCode)TC0000147485 035 $a(PQKBWorkID)10012489 035 $a(PQKB)11244900 035 $a(MiAaPQ)EBC427695 035 $a(EXLCZ)991000000000719525 100 $a20080522d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe engineering design of systems$b[electronic resource] $emodels and methods /$fDennis M. Buede 205 $a2nd ed. 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2009 215 $a1 online resource (532 p.) 225 1 $aWiley series in systems engineering and management 300 $aDescription based upon print version of record. 311 $a0-470-16402-6 320 $aIncludes bibliographical references (p. 487-501) and index. 327 $aTHE ENGINEERING DESIGN OF SYSTEMS; Contents; Preface; Part 1 Introduction, Overview, and Basic Knowledge; Chapter 1 Introduction to Systems Engineering; Chapter 2 Overview of the Systems Engineering Design Process; Chapter 3 Modeling and SysML Modeling; Chapter 4 Discrete Mathematics: Sets, Relations, and Functions; Chapter 5 Graphs and Directed Graphs (Digraphs); Part 2 Design and Integration; Chapter 6 Requirements and Defining the Design Problem; Chapter 7 Functional Architecture Development; Chapter 8 Physical Architecture Development; Chapter 9 Allocated Architecture Development 327 $aChapter 10 Interface DesignChapter 11 Integration and Qualification; Part 3 Supplemental Topics; Chapter 12 Graphical Modeling Techniques; Chapter 13 Decision Analysis for Design Trades; Appendix A: Outline of Systems Engineering Documents; Appendix B: IDEF0 Model of the Engineering of a System; Glossary; References; Historical References; Index 330 $aThe ideal introduction to the engineering design of systems-now in a new edition The Engineering Design of Systems, Second Edition compiles a wealth of information from diverse sources to provide a unique, one-stop reference to current methods for systems engineering. It takes a model-based approach to key systems engineering design activities and introduces methods and models used in the real world. Features new to this edition include: The addition of Systems Modeling Language (SysML) to several of the chapters, as well as the introduction of new terminology A 410 0$aWiley series in systems engineering and management. 606 $aSystems engineering 606 $aEngineering design 606 $aSystem design 615 0$aSystems engineering. 615 0$aEngineering design. 615 0$aSystem design. 676 $a620.001/171 676 $a620.001171 676 $a620.0042 700 $aBuede$b Dennis M$0981668 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830680503321 996 $aThe engineering design of systems$93929130 997 $aUNINA LEADER 04439nam 2201117z- 450 001 9910367740903321 005 20210211 010 $a3-03921-689-9 035 $a(CKB)4100000010106308 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/45547 035 $a(oapen)doab45547 035 $a(EXLCZ)994100000010106308 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDual Specificity Phosphatases: From Molecular Mechanisms to Biological Function 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 online resource (240 p.) 311 08$a3-03921-688-0 330 $aDual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease. 517 $aDual Specificity Phosphatases 606 $aBiology, life sciences$2bicssc 610 $aasthma 610 $aastrocytes 610 $aatypical dual-specificity phosphatases 610 $aatypical DUSP 610 $aBDNF 610 $abrain metastasis 610 $acancer 610 $acannabinoids 610 $acirculating tumor cells (CTCs) 610 $aCOPD 610 $aCpp1 610 $acytokines 610 $aDEPArray 610 $adifferentiation 610 $adual-specificity phosphatase 610 $adual-specificity phosphatases 610 $aDUSP-4 610 $aDUSP10 610 $aE. coli infection 610 $afungal MKPs 610 $agranule neurons 610 $aHDAC6 (histone deacetylase isoform 6) 610 $ahematopoietic cells 610 $aHER2 610 $ahypertriglyceridemia 610 $ainflammation 610 $ainfluenza 610 $aintegrated omics analysis 610 $aliver steatosis 610 $amacrophage 610 $amacrophages 610 $aMAP Kinase Phosphatase-2 610 $aMAP kinase phosphatases 610 $aMAP kinases 610 $aMAPK 610 $aMAPK phosphatase 610 $aMAPKs 610 $amicrotubules 610 $amitogen-activated protein kinase 610 $aMK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein) 610 $aMkp-1 610 $aMsg5 610 $an/a 610 $aneuroblastoma 610 $aneuronal differentiation 610 $anucleotide receptors 610 $aP2X7 610 $aP2Y13 610 $aPmp1 610 $apost-translational modification 610 $aproliferation 610 $aprotein stability 610 $apseudophosphatase 610 $arespiratory viruses 610 $arhinovirus 610 $aRSV 610 $aSdp1 610 $asepsis 610 $asignaling 610 $asingle cell analysis 610 $aT cell 610 $aTLR signaling 610 $atriple-negative breast cancer (TNBC) 610 $aubiquitination 615 7$aBiology, life sciences 700 $aPulido$b Rafael$4auth$01323466 702 $aLang$b Roland$4auth 906 $aBOOK 912 $a9910367740903321 996 $aDual Specificity Phosphatases: From Molecular Mechanisms to Biological Function$93035585 997 $aUNINA