LEADER 03792nam 2200865z- 450 001 9910367738803321 005 20210211 010 $a3-03921-937-5 035 $a(CKB)4100000010106329 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/46650 035 $a(oapen)doab46650 035 $a(EXLCZ)994100000010106329 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aEnzyme-Mediated Stereoselective Synthesis 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 online resource (116 p.) 311 08$a3-03921-936-7 330 $aThis book is a collection of studies focused on the exploitation of enzyme stereoselectivity for the synthesis of relevant chemicals, such as innovative materials, chiral building blocks, natural products, and flavor and fragrance compounds. Different catalytic approaches are reported. The first study describes a resolution-based process for the stereoselective synthesis of the enantiomeric forms of the flavor compound linaloyl oxide, whereas other enantiomeric enriched aroma compounds were obtained through a novel microbial approach based on solid-state fermentation. Two relevant works exploit the potential of the biocatalyzed reduction reactions. The first of these contributions describes the enantioselective synthesis of ?-nitroalcohols by enzyme-mediated reduction of ?-nitroketones, whereas a second contribution reports the preparation of chiral 1,4-diaryl-1,4-diols through ADH-catalyzed bioreduction of the corresponding diketones. Concerning enantioenriched alcohol derivatives, natural hydroxy fatty acids are prepared by means of the biocatalytic hydration reaction of natural fatty acids using the probiotic bacterium Lactobacillus rhamnosus as a whole-cell biocatalyst. Further studies describe the use of modified pullulan polysaccharide for lipase immobilization and the recent advances in synthetic applications of ?-transaminases for the production of chiral amines. 606 $aChemistry$2bicssc 610 $a?-transaminases 610 $a1 610 $a1-phenylethanol 610 $a4-diols 610 $aagro-industrial side stream 610 $aalcohol dehydrogenases 610 $aalcohol-dehydrogenase 610 $aaroma compounds 610 $aasymmetric synthesis 610 $abiocatalysis 610 $abioreduction 610 $aBurkholderia cepacia lipase 610 $achiral amines 610 $achiral resolution 610 $acyclization 610 $adiketones 610 $aenantioselective synthesis 610 $aenantioselectivity 610 $aenzyme-mediated resolution 610 $aesters 610 $aflavors 610 $ahydratase 610 $ahydroxy fatty acids 610 $aimmobilization 610 $akinetic resolution 610 $aLactobacillus rhamnosus 610 $alactones 610 $alinalool 610 $alinaloyl oxide 610 $alinoleic acid 610 $alinolenic acid 610 $alinseed cake 610 $alipases 610 $amonoterpenes 610 $amulti-enzymatic cascades 610 $an/a 610 $anitroketone 610 $aoleic acid 610 $aprotein engineering 610 $apullulan 610 $arapeseed cake 610 $areaction engineering 610 $areduction 610 $asolid-state fermentation 610 $astereoselective biotransformation 615 7$aChemistry 700 $aSerra$b Stefano$4auth$0749518 906 $aBOOK 912 $a9910367738803321 996 $aEnzyme-Mediated Stereoselective Synthesis$93021366 997 $aUNINA