LEADER 04084nam 2200973z- 450 001 9910367737603321 005 20231214133235.0 010 $a3-03921-851-4 035 $a(CKB)4100000010106341 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53201 035 $a(EXLCZ)994100000010106341 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMERS-CoV 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (274 p.) 311 $a3-03921-850-6 330 $aMiddle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic coronavirus. First identified in 2012, MERS-CoV has caused over 2460 infections and a fatality rate of about 35% in humans. Similar to severe acute respiratory syndrome coronavirus (SARS-CoV), MERS-CoV likely originated from bats; however, different from SARS-CoV, which potentially utilized palm civets as its intermediate hosts, MERS-CoV likely transmits to humans through dromedary camels. Animal models, such as humanized mice and nonhuman primates, have been developed for studying MERS-CoV infection. Currently, there are no vaccines and therapeutics approved for the prevention and treatment of MERS-CoV infection, although a number of them have been developed preclinically or tested clinically. This book covers one editorial and 16 articles (including seven review articles and nine original research papers) written by researchers working in the field of MERS-CoV. It describes the following three main aspects: (1) MERS-CoV epidemiology, transmission, and pathogenesis; (2) current progress on MERS-CoV animal models, vaccines, and therapeutics; and (3) challenges and future prospects for MERS-CoV research. Overall, this book will help researchers in the MERS-CoV field to further advance their work on the virus. It also has important implications for other coronaviruses as well as viruses outside the coronavirus family with pandemic potentials. 610 $acell?cell fusion 610 $ahDPP4 610 $an/a 610 $atherapeutics 610 $aanimal models 610 $aHCoV-229E 610 $aDrivers 610 $acamels 610 $arabbits 610 $aSARS-CoV 610 $aMERS-CoV 610 $aMVA vaccine 610 $atransmission 610 $aRBD 610 $aMERS-CoV nucleocapsid protein 610 $acomplement 610 $aanimal model 610 $apseudotyped virus 610 $acombination 610 $aMERS-coronavirus 610 $apeptide 610 $amouse model 610 $aspike protein 610 $areceptor-binding domain 610 $aprevention and treatment 610 $acoronaviruses 610 $acoronavirus spike glycoprotein 610 $atherapeutic antibodies 610 $avaccine platforms 610 $amutation 610 $asevere acute respiratory syndrome coronavirus 610 $apathogenesis 610 $afusion inhibitor 610 $aCoronavirus 610 $amurine CD8+ T cell epitope 610 $alipidomics 610 $aauthentic virus 610 $acorrelates of immunity 610 $avaccines 610 $aneutralizing monoclonal antibodies 610 $aMiddle East respiratory syndrome coronavirus 610 $asmall-molecule inhibitor 610 $aMiddle East Respiratory Syndrome Virus 610 $aDPP4 610 $apyroptosis 610 $across-neutralization 610 $ainflammation 610 $aQatar 610 $aspike proteins 610 $aOne Health 610 $aHKU4 610 $ananobodies 610 $amechanism of action 610 $aneutralizing antibody 610 $ahost factors 610 $aUHPLC?MS 700 $aDu$b Lanying$4auth$01322339 702 $aLi$b Fang$4auth 906 $aBOOK 912 $a9910367737603321 996 $aMERS-CoV$93034884 997 $aUNINA