LEADER 03881nam 2200769z- 450 001 9910367737103321 005 20210211 010 $a3-03921-949-9 035 $a(CKB)4100000010106346 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42797 035 $a(oapen)doab42797 035 $a(EXLCZ)994100000010106346 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCatalyzed Synthesis of Natural Products 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 online resource (82 p.) 311 08$a3-03921-948-0 330 $aNatural products have been a source of inspiration for chemists and chemical biologists for many years, and have a special relevance in the chemical space. In recent years, several novel synthetic strategies have appeared, such as diversity-oriented synthesis (DOS), biological-oriented synthesis (BiOS), and function-oriented synthesis (FOS), for accessing complex and functionally diverse molecules. In this manner, the synthesis of natural products has evolved towards simpler and ecological methods using biotransformation, combinatorial chemistry, or organocatalysts. In this issue, Prof. Chojnacka shows demonstrates the use of immobilized lipases as catalysts to aid in the synthesis of phosphatidylcholine enriched with myristic acid. Profs. Vila and Pedro used catalysts derived from (S)-mandelic acid to achieve the catalytic enantioselective addition of dimethylzinc to isatins. Prof. Diez shows the possibility of the obtention of 7,8-carvone epoxides in a diastereoselective manner using proline, quinidine, and diphenylprolinol as organocatalysts. A cheap, simple, clean, and scalable method involves the use of deep eutectic mixtures as reaction media, and Profs. Alonso and Guillena describe the use of this methodology for the enantioselective, organocatalyzed ?-amination of 1,3-dicarbonyl compounds. Biotransformations have been one of the methodologies for more efficient synthesis of natural products. Prof. Wu transforms ergostane triterpenoid antcin K using Psychrobacillus sp. Ak 187. Finally, Prof. Kovayashi reviews the total synthesis and biological evaluation of phaeosphaerides. The reader, through this issue, could gain an idea of the new directions that the synthesis of natural products using catalysts will have in the years to come. 606 $aChemistry$2bicssc 610 $a?-amination 610 $a3-hydroxyoxindole 610 $aacidolysis 610 $aaminocatalysis 610 $aantcin K 610 $aanticancer 610 $aAntrodia cinnamomea 610 $aasymmetric catalysis 610 $aasymmetric organocatalysis 610 $abenzimidazole 610 $abiotransformation 610 $acarvone 610 $achiral ?-hydroxyamide 610 $adeep eutectic solvents 610 $aegg-yolk phosphatidylcholine 610 $aepoxidation 610 $aepoxide 610 $agreen chemistry 610 $aimmobilized lipases 610 $ainteresterification 610 $aisatin 610 $amandelamides 610 $amyristic acid 610 $an/a 610 $anatural products 610 $aorganocatalysis 610 $aphaeosphaeride A 610 $aphaeosphaeride B 610 $aproline 610 $aPsychrobacillus 610 $aSTAT3 610 $astructural revision 610 $astructured phosphatidylcholine 610 $atotal synthesis 610 $atrimyristin 610 $atriterpenoid 610 $azinc 615 7$aChemistry 700 $aDíez$b David$4auth$01304417 906 $aBOOK 912 $a9910367737103321 996 $aCatalyzed Synthesis of Natural Products$93027384 997 $aUNINA