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010   $a3-03921-356-3
035   $a(CKB)4100000010106067
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40469
035   $a(EXLCZ)994100000010106067
100   $a20202102d2019      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAging and Age-related Disorders: From Molecular Mechanisms to Therapies
210   $cMDPI - Multidisciplinary Digital Publishing Institute$d2019
215   $a1 electronic resource (322 p.)
311   $a3-03921-355-5 
330   $aAging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson?s, Alzheimer?s, and Huntington?s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.
517   $aAging and Age-related Disorders
610   $aadvanced glycated end products
610   $amicroRNAs
610   $adifferentiation
610   $atranscription
610   $askin absorption
610   $acellular quiescence
610   $alifespan
610   $alongevity genes
610   $aprotein kinases
610   $aself-renewal
610   $acircadian
610   $ablood-brain barrier
610   $aaging-related disorders
610   $asirtuin-1
610   $ainflammation
610   $aarterial aging
610   $areactive oxygen species
610   $aelectron microscopy
610   $areconstructed human skin
610   $arejuvenation
610   $alow-dose fluvastatin and valsartan combination
610   $ainflammaging
610   $ahematopoietic stem cell aging
610   $acell cycle
610   $amitochondria
610   $aribose
610   $athe nervous system
610   $ananomedicine
610   $aproteostasis
610   $aadult stem cells
610   $aimmunosenescence
610   $acell signaling
610   $amechanisms of quiescence maintenance
610   $ametabolism
610   $aaging
610   $amelatonin
610   $adiabetes
610   $amechanisms of quiescence entry and exit
610   $aDrosophila melanogaster
610   $aGSK3 (glycogen synthase kinase 3)
700   $aTitorenko$b Vladimir$4auth$01317912
906   $aBOOK
912   $a9910367567903321
996   $aAging and Age-related Disorders: From Molecular Mechanisms to Therapies$93033084
997   $aUNINA