LEADER 03621nam 2200877z- 450 001 9910367567503321 005 20231214133513.0 010 $a3-03921-244-3 035 $a(CKB)4100000010106071 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48248 035 $a(EXLCZ)994100000010106071 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aG-quadruplex and Microorganisms 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (208 p.) 311 $a3-03921-243-5 330 $aG-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV-1), human papilloma virus, swine pseudorabies virus, and other viruses? genomes. New evidence shows the presence of G4s in parasitic protozoa, such as the causative agent of malaria. G4 binding proteins and mRNA G4s have been implicated in the regulation of microorganisms? genome replication and translation. G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle and as therapeutic agents. Moreover, new techniques to study G4 folding and their interactions with proteins have been developed. This Special Issue will focus on G4s present in microorganisms, addressing all the above aspects. 610 $abacteria 610 $afolding 610 $aco-translational refolding 610 $aRecQ helicase 610 $aregulatory element 610 $aconformational dynamics 610 $aG4Hunter 610 $aNDPK 610 $afluorescence 610 $apseudorabies virus 610 $aEpstein-Barr virus (EBV) 610 $astructure-activity relationship 610 $aPhenDC3 610 $aeukaryotic hosts 610 $aHerpesvirus 610 $atranslation suppression 610 $aturn-on ligands 610 $aco-transcriptional folding 610 $aHerpesviridae 610 $aG-quadruplex 610 $anucleoside diphosphate kinase 610 $anucleic acids 610 $anucleic acids conformation 610 $abioinformatics 610 $aprotein?DNA interaction 610 $aaptamers 610 $adeinococcus 610 $aAlphaherpesvirinae 610 $aEBNA1 610 $aG4 610 $avirus 610 $ahuman papillomaviruses 610 $aS. cerevisiae 610 $agenome stability 610 $aG-quadruplexes 610 $ametastable structure 610 $agenome evolution 610 $apyridostatin 610 $aalphaherpesviruses 610 $astructure 610 $aprotozoa 610 $agenome 610 $aG-quadruplex ligand 610 $aNMR 610 $amicrobes 610 $aDNA 610 $aprotein-mRNA interactions 610 $aG-quadruplex formation 610 $aimmediate early promoters 700 $aRichter$b Sara N$4auth$01331588 906 $aBOOK 912 $a9910367567503321 996 $aG-quadruplex and Microorganisms$93040468 997 $aUNINA