LEADER 04785nam 22012373a 450 001 9910367565003321 005 20250203235429.0 010 $a9783039213498 010 $a3039213490 024 8 $a10.3390/books978-3-03921-349-8 035 $a(CKB)4100000010106096 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/46256 035 $a(ScCtBLL)a4cb6b35-6d39-4ec9-8692-92e5909e0640 035 $a(OCoLC)1163835224 035 $a(oapen)doab46256 035 $a(EXLCZ)994100000010106096 100 $a20250203i20192019 uu 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aEmerging Marine Biotoxins$fArjen Gerssen, Ana Gago-Martínez 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 210 1$aBasel, Switzerland :$cMDPI,$d2019. 215 $a1 electronic resource (206 pages) 311 08$a9783039215133 311 08$a3039215132 330 $aThe emergence of marine and freshwater toxins in geographical areas where they have never been reported before is a concern due to the considerable impact on (sea)food contamination, and consequently, on public health. Several groups of marine biotoxins, in particular tetrodotoxins, ciguatoxins, and palytoxins, are included among the relevant marine biotoxins that have recently emerged in several coastal areas. A similar situation has been observed in freshwater, where cyanobacterial toxins, such as microcystins, could end up in unexpected areas such as the estuaries where shellfish are cultivated. Climate change and the increased availability of nutrients have been considered as the key factors in the expansion of all of these toxins into new areas; however, this could also be due to more intense biological invasions, more sensitive analytical methods, or perhaps even an increased scientific interest in these natural contaminations. The incidences of human intoxications due to the consumption of seafood contaminated with these toxins have made their study an important task to accomplish in order to protect human health. This Special Issue has a focus on a wide variety of emerging biotoxin classes and techniques to identify and quantify them. 606 $aBiology, life sciences$2bicssc 607 $aMurntuluk / Catfish (Central NT, North NT SE52-03)$2aiatsisp 610 $aC-CTX-1 610 $anon-targeted analysis 610 $aciguatera fish poisoning 610 $asuspects screening 610 $aneurodegeneration 610 $aadaptation 610 $aLC-HRMS 610 $aparalytic shellfish toxins 610 $aLC-MS/MS 610 $aanimal toxins 610 $aidentification 610 $amethod characterization 610 $acaribbean ciguatoxins 610 $aoral toxicity 610 $awater flea 610 $aquorum sensing 610 $aeutrophication 610 $abeta-methyl-amino-l-alanine 610 $adynamics simulation 610 $athermal water 610 $aspent medium 610 $aMicrocystis 610 $aGambierdiscus 610 $agambierdiscus 610 $awhole genome sequencing 610 $apalytoxin 610 $aconotoxin 610 $aovatoxins 610 $acyanobacterial toxin 610 $aBMAA 610 $aCiguatera fish poisoning 610 $aRastrineobola argentea 610 $acalcium-activated K+ ion channel 610 $atoxicity equivalence factor 610 $aNMR spectroscopy 610 $aN2a 610 $aPPIA 610 $amarine biotoxins 610 $aDaphnia magna 610 $aELISA 610 $adisulfide-rich peptide 610 $afood chain 610 $aShK-like peptide 610 $avoltage-gated K+ ion channel 610 $atargeted analysis 610 $aChinese yellow catfish 610 $amarine 610 $amacaronesia 610 $aneuroblastoma bioassay 610 $amarine toxins 610 $aacute toxicity 610 $aalgal-bacterial relationship 610 $amass spectrometry 610 $atetrodotoxins 610 $asaxitoxin 610 $atoxicology 610 $acationization 610 $aseafood safety 610 $aevolution 610 $acyanotoxins 610 $atoxin genes 610 $azoantharian 610 $aspatial variability 610 $adopaminergic neurons 610 $atetrodotoxin 610 $abivalve mollusks 615 7$aBiology, life sciences 700 $aGerssen$b Arjen$01297596 702 $aGago-Martínez$b Ana 801 0$bScCtBLL 801 1$bScCtBLL 906 $aBOOK 912 $a9910367565003321 996 $aEmerging Marine Biotoxins$93024593 997 $aUNINA LEADER 03854nam 2200925z- 450 001 9910557110203321 005 20210501 035 $a(CKB)5400000000040945 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69057 035 $a(oapen)doab69057 035 $a(EXLCZ)995400000000040945 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPeptide Nucleic Acids$eApplications in Biomedical Sciences 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (154 p.) 311 08$a3-03936-886-9 311 08$a3-03936-887-7 330 $aThis book compiles four review articles and four research papers that highlight recent developments in the field of peptide nucleic acid (PNA) chemistry and biomedicine. The review articles encompass a variety of fields related to PNA, emphasizing the versatility of this DNA mimic. Two excellent reviews detail the use of PNA for molecular diagnostics of miRNAs and genetic point mutations (SNPs). Another review provides a comprehensive analysis of the various approaches for gene editing using chemically modified PNA molecules. Lastly, PNA molecules are elegantly described as effective (antisense) antimicrobial agents in the final review. The high binding affinity of PNA to complementary DNA and RNA is highlighted in three research articles. Two articles show how PNA molecules act as splice modulating and RNA masking molecules, separately. In another contribution, the high affinity and achiral characteristics of PNAs are used to developed a stable L-DNA-based catalytic hairpin assembly. Lastly, chemically-modified PNA molecules are shown to be superior probes for SNP detection. Altogether, these studies illustrate how PNA molecules may be useful for a variety of biomedical applications as either therapeutic or diagnostic agents. 517 $aPeptide Nucleic Acids 606 $aMedicine and Nursing$2bicssc 610 $aantibacterials 610 $aantisense 610 $abacterial resistance 610 $acancer. 610 $acatalytic hairpin assembly (CHA) 610 $aCFTR 610 $acolorimetric detection 610 $aconjugates 610 $acystic fibrosis 610 $adelivery 610 $adrug resistance 610 $aelectrochemical biosensors 610 $aexon inclusion 610 $aexon skipping 610 $afluorescence 610 $agene editing 610 $ainfluenza virus 610 $al-DNA 610 $alight-triggered 610 $amicroRNA 610 $amicroRNAs 610 $amiR-145-5p 610 $amiRNA targeting 610 $an/a 610 $ananoparticles 610 $aoligonucleotides 610 $apeptide nucleic acid 610 $apeptide nucleic acid (PNA) 610 $apeptide nucleic acids 610 $aPeptide nucleic acids 610 $apeptide nucleic acids (PNAs) 610 $aPNA 610 $aPNA transporters 610 $aPNA-masking 610 $apolymerase chain reaction (PCR) 610 $arecombination 610 $arepair 610 $aRNA 610 $aRNA structure 610 $asingle nucleotide polymorphism 610 $asingle-nucleotide polymorphism (SNP) 610 $astrand invasion 610 $astrand-displacement reaction 610 $astructure 610 $atemplated reactions 610 $atolane 610 $atriplex 610 $a?-thalassemia 615 7$aMedicine and Nursing 700 $aYavin$b Eylon$4edt$01290288 702 $aYavin$b Eylon$4oth 906 $aBOOK 912 $a9910557110203321 996 $aPeptide Nucleic Acids$93021451 997 $aUNINA