LEADER 05668nam 2201633z- 450 001 9910367564903321 005 20231214133710.0 010 $a3-03921-390-3 035 $a(CKB)4100000010106097 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/45331 035 $a(EXLCZ)994100000010106097 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDNA Replication Stress 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (368 p.) 311 $a3-03921-389-X 330 $aThis Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology. 610 $aWerner Syndrome 610 $aA549 cells 610 $aepigenetic 610 $aneurodegeneration 610 $aGenome integrity 610 $aadaptation 610 $acellular senescence 610 $agenome instability 610 $aWerner Syndrome Protein 610 $alipofuscin 610 $acell cycle checkpoints 610 $aexonuclease 1 610 $atemplate-switching 610 $aenergy metabolism 610 $amutation frequency 610 $aDNA replication 610 $afork regression 610 $amotor neuron disease 610 $aMicrosatellites 610 $aAlzheimer's disease 610 $achromatin remodeler 610 $arepair of DNA damage 610 $aAP site analogue 610 $amutagens 610 $areplication timing 610 $aThermococcus eurythermalis 610 $anucleolar stress 610 $agene expression 610 $amutations spectra 610 $aorigin firing 610 $aFanconi Anemia 610 $asuperfamily 2 ATPase 610 $aDNA translocation 610 $aDNA repair 610 $aSSB signaling 610 $ahomologous recombination 610 $acommon fragile sites 610 $a8-chloro-adenosine 610 $areplication 610 $agenome stability 610 $amutagenicity 610 $afork reversal 610 $amultiple sclerosis 610 $anon-B DNA 610 $aprotein stability 610 $aheterogeneity 610 $aubiquitin 610 $aSenTraGorTM (GL13) 610 $areplication restart 610 $aEdU 610 $a?-arrestin 610 $aNER 610 $aaging 610 $aSSB end resection 610 $aoxidative stress 610 $aATR 610 $adormant origins 610 $aR loops 610 $aDNA damage response 610 $aDifficult-to-Replicate Sequences 610 $aDNA double-strand repair 610 $aendonuclease IV 610 $aALS 610 $adouble strand break repair 610 $apremature aging 610 $areplication stress 610 $aEXO1 610 $aPOL? 610 $atranslesion synthesis 610 $astrand displacements 610 $aG2-arrest 610 $aDNA replication pattern 610 $aSSB repair 610 $agenome integrity 610 $aG protein-coupled receptor kinase interacting protein 2 (GIT2) 610 $aMMR 610 $areplicative stress 610 $asenolytics 610 $aspacer 610 $ainteractome 610 $aATR-Chk1 DDR pathway 610 $aC9orf72 610 $areplication fork restart 610 $atranslesion DNA synthesis 610 $aDNA damage 610 $amismatch repair 610 $aDNA replication stress 610 $aDNA helicase 610 $aPolymerase kappa 610 $aDNA fiber assay 610 $aH1299 cells 610 $aTLS 610 $aAPE2 610 $aageing 610 $acell death 610 $achromosome 610 $aTopBP1 610 $abarley 610 $aclock proteins 610 $apost-translational modification 610 $a8-oxoG 610 $aS phase 610 $aataxia telangiectasia mutated (ATM) 610 $aG protein-coupled receptor (GPCR) 610 $aPolymerase eta 610 $acancer 610 $aG protein-coupled receptor kinase (GRK) 610 $ahelicase 610 $agenomic instability 610 $aParkinson's disease 610 $anucleotide excision repair 610 $aSupF 700 $aBrosh Jr$b Robert M$4auth$01332974 906 $aBOOK 912 $a9910367564903321 996 $aDNA Replication Stress$93041176 997 $aUNINA