LEADER 03386nam 2200613 a 450 001 9910789405703321 005 20230725031500.0 010 $a1-283-14332-1 010 $a9786613143327 010 $a1-84816-367-3 035 $a(CKB)2670000000095736 035 $a(EBL)731333 035 $a(OCoLC)738434150 035 $a(SSID)ssj0000524181 035 $a(PQKBManifestationID)12213183 035 $a(PQKBTitleCode)TC0000524181 035 $a(PQKBWorkID)10546100 035 $a(PQKB)11062794 035 $a(MiAaPQ)EBC731333 035 $a(WSP)0000P630 035 $a(Au-PeEL)EBL731333 035 $a(CaPaEBR)ebr10479770 035 $a(CaONFJC)MIL314332 035 $a(EXLCZ)992670000000095736 100 $a20110714d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMicroRNAs in development and cancer$b[electronic resource] /$feditor, Frank J. Slack 210 $aLondon $cImperial College Press$d2011 215 $a1 online resource (300 p.) 225 1 $aMolecular medicine and medicinal chemistry ;$vv. 1 300 $aDescription based upon print version of record. 311 $a1-84816-366-5 320 $aIncludes bibliographical references and index. 327 $aContents; Preface; 1 Introduction to Gene Regulation by Small RNAs Allison L. Abbott; 2 The Emerging Non-Coding RNA World Ahmad M. Khalil, Maite Huarte and John L. Rinn; 3 MicroRNAs in C. elegans Development Helge Großhans and Almuth E. Mu?llner; 4 MicroRNAs in Mammalian Development Andrea Ventura; 5 MicroRNAs in Hematopoietic Development Silvia Monticelli; 6 MicroRNAs Function as Tumor Suppressor Genes and Oncogenes Aurora Esquela-Kerscher; 7 Simultaneous Detection of Primary, Precursor and Mature MicroRNAs by qPCR Jinmai Jiang, Eun Joo Lee and Thomas D. Schmittgen 327 $a8 Single Nucleotide Polymorphisms in MicroRNAs and MicroRNA Binding Sites with Roles in Cancer Lena J. Chin and Frank J. Slack9 MicroRNAs as Potential Diagnostics and Therapeutics Trupti Paranjape, Jae Choi and Joanne B.Weidhaas; 10 MicroRNA Target Prediction Isidore Rigoutsos and Aristotelis Tsirigos; 11 Non-Coding RNAs in Cancer - The Other Part of the Story Muller Fabbri and George A. Calin; Index 330 $aMicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represen 410 0$aMolecular medicine and medicinal chemistry ;$vv. 1. 606 $aCancer$xGenetic aspects 606 $aSmall interfering RNA 615 0$aCancer$xGenetic aspects. 615 0$aSmall interfering RNA. 676 $a572.88 701 $aSlack$b Frank J$01487345 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910789405703321 996 $aMicroRNAs in development and cancer$93707141 997 $aUNINA LEADER 02476oam 2200529I 450 001 9910366060003321 005 20210104165725.0 035 $a(OCoLC)942028725 035 $a(OCoLC)ocn942028725 035 $a(EXLCZ)9913590434600041 100 $a20160301d2013 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$a2011 standard for performance rating of water-chilling and heat pump water heating packages using the vapor compression cycle 210 1$aArlington, VA :$cAir-Conditioning & Refrigeration Institute,$d[2013] 215 $a1 online resource (1 volume (various pagings)) $cillustrations (some color) 300 $aTitle from title screen (viewed March 1, 2016). 300 $a"September 2013." 311 08$aReproduction of (manifestation): 2011 standard for performance rating of water-chilling and heat pump water heating packages using the vapor compression cycle. Arlington, VA : Air-Conditioning & Refrigeration Institute, [2013] (OCoLC)942037305 320 $aIncludes bibliographical references (pages 30-31). 517 3 $aPerformance rating of water-chilling and heat pump water heating packages using the vapor compression cycle 517 3 $aANSI/AHRI standard 550/590 (I-P) with addendum 3 517 3 $aAHRI standard 550/590 (I-P) with addendum 3 606 $aHeat pumps$xEquipment and supplies$xTesting 606 $aHeat pumps$xEquipment and supplies$xEvaluation 606 $aCompressors$xTesting 606 $aRefrigeration and refrigerating machinery$xStandards 606 $aCompressors$xTesting$2fast$3(OCoLC)fst00871908 606 $aRefrigeration and refrigerating machinery$xStandards$2fast$3(OCoLC)fst01092741 615 0$aHeat pumps$xEquipment and supplies$xTesting. 615 0$aHeat pumps$xEquipment and supplies$xEvaluation. 615 0$aCompressors$xTesting. 615 0$aRefrigeration and refrigerating machinery$xStandards. 615 7$aCompressors$xTesting. 615 7$aRefrigeration and refrigerating machinery$xStandards. 712 02$aAir-Conditioning and Refrigeration Institute. 801 0$bWE2 801 1$bWE2 801 2$bWE2 801 2$bOCLCQ 801 2$bOCLCF 912 $a9910366060003321 996 $a2011 standard for performance rating of water-chilling and heat pump water heating packages using the vapor compression cycle$92074243 997 $aUNINA LEADER 04987nam 2200469z 450 001 9910158677303321 005 20221215205021.0 010 $a4-627-30441-2 035 $a(CKB)3710000000612520 035 $a(JP-MeL)3000025634 035 $a(MiAaPQ)EBC5328633 035 $a(Au-PeEL)EBL5328633 035 $a(CaPaEBR)ebr11533896 035 $a(OCoLC)1030027461 035 $a(JP-MeKC)3000429515 035 $a(EXLCZ)993710000000612520 100 $a20211007d2014 ||| | 101 0 $ajpn 135 $aur|n||||un||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$a????? ??? 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