LEADER 04583nam 22006135 450 001 9910357829303321 005 20220214193946.0 010 $a3-030-31668-8 024 7 $a10.1007/978-3-030-31668-6 035 $a(CKB)4100000009759125 035 $a(DE-He213)978-3-030-31668-6 035 $a(MiAaPQ)EBC5974943 035 $a(PPN)258306920 035 $a(EXLCZ)994100000009759125 100 $a20191107d2019 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNanovaccines $eAn Innovative Technology to Fight Human and Animal Diseases /$fby Sergio Rosales-Mendoza, Omar González-Ortega 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (X, 343 p. 89 illus., 62 illus. in color.) 311 $a3-030-31667-X 320 $aIncludes bibliographical references and index. 327 $aChapter 1. Nanovaccines and the history of vaccinology -- Chapter 2. The mucosal immune system an outlook for nanovaccines development -- Chapter 3. Gold-based mucosal nanovaccines -- Chapter 4. PLGA-based mucosal nanovaccines -- Chapter 5. Silica-based mucosal nanovaccines -- Chapter 6. Nanogels-based mucosal vaccines -- Chapter 7. Carbon nanotubes-based mucosal vaccines -- Chapter 8. Chitosan-based mucosal nanovaccines -- Chapter 9. Liposomes-based mucosal nanovaccines -- Chapter 10. Virus-like particles-based mucosal nanovaccines -- Chapter 11. Perspectives for field of nanovaccines. 330 $aThis book provides a compilation of the current developments in mucosal nanovaccines, which are an attractive approach to fight against infectious and non-communicable diseases. Since nanomaterials possess unique properties; many of them have a positive effect on vaccine efficacy when used as antigen carriers and have been applied in vaccinology with significant advances over the past years. This book addresses the methodologies for mucosal nanovaccines synthesis; based on the following nanomaterials: gold, PLGA, silica, and chitosan nanoparticles; as well as nanogels, carbon nanotubes, liposomes, and Virus-like particles. A description of the immunogenic properties of the mucosal nanovaccines is presented, highlighting the improvements achieved with this approach when compared to conventional formulations. Mucosal vaccines constitute the most practical immunization approach since they are easy to administer (promoting patient´s comfort and increasing compliance), allow triggering relevant immune responses at both the site of administration and distant compartments, and thus may protect the main entry portal for pathogens (oral, nasal, and genital mucosae). In this context, the potential of nanovaccines to result in new mucosal formulations in the benefit of global health is analyzed. Covers the synthesis and functionalization of nanomaterials for the development of nanovaccines; Discusses the underlying mechanisms involved in the induction of immune responses through mucosal compartments and the advantages of nanomaterials in the formulation of nanovaccines; Transmits the state of the art for the development of mucosal nanovaccines; Provides routes for the design and evaluation of mucosal nanovaccines; Presents key perspectives for the field of mucosal vaccine development. 606 $aBiomaterials 606 $aMedicinal chemistry 606 $aVaccines 606 $aNanotechnology 606 $aBiomaterials$3https://scigraph.springernature.com/ontologies/product-market-codes/Z13000 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aVaccine$3https://scigraph.springernature.com/ontologies/product-market-codes/B16010 606 $aNanotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/Z14000 615 0$aBiomaterials. 615 0$aMedicinal chemistry. 615 0$aVaccines. 615 0$aNanotechnology. 615 14$aBiomaterials. 615 24$aMedicinal Chemistry. 615 24$aVaccine. 615 24$aNanotechnology. 676 $a620.11 700 $aRosales Mendoza$b Sergio$4aut$4http://id.loc.gov/vocabulary/relators/aut$0781335 702 $aGonzález-Ortega$b Omar$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910357829303321 996 $aNanovaccines$92520066 997 $aUNINA