LEADER 04679 am 22007093u 450 001 9910353342603321 005 20231006212016.0 010 $a3-318-02730-8 035 $a(CKB)3710000000281125 035 $a(EBL)3016640 035 $a(SSID)ssj0001379209 035 $a(PQKBManifestationID)12603897 035 $a(PQKBTitleCode)TC0001379209 035 $a(PQKBWorkID)11370728 035 $a(PQKB)11328704 035 $a(MiAaPQ)EBC3016640 035 $a(ScCtBLL)08d0513c-f9f8-46b3-be57-53e19d095343 035 $a(SZ-BaSKA)261901 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/37351 035 $a(PPN)198027613 035 $a(OCoLC)897212853 035 $a(EXLCZ)993710000000281125 100 $a20140710h20152015 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAging and health $ea systems biology perspective /$fvolume editors, Anatoliy I. Yashin, S. Michal Jazwinski 210 $cKarger$d2014 210 1$aBasel ;$aNew York :$cKarger,$d[2015] 210 4$dİ2015 215 $a1 online resource (208 p.) 225 1 $aInterdisciplinary topics in gerontology,$x0074-1132 ;$vvolume 40 300 $aDescription based upon print version of record. 311 $a1-322-39629-9 311 $a3-318-02729-4 320 $aIncludes bibliographical references and indexes. 327 $aIntroduction to the theory of aging networks / Witten, T.M. -- Applications to aging networks / Wimble, C., Witten, T.M. -- Computational systems biology for aging research / Auley, M.T., Mooney, K.M. -- How does the body know how old it is? Introducing the epigenetic clock hypothesis / Mitteldorf, J. -- The great evolutionary divide : two genomic systems biologies of aging / Rose, M.R., Cabral, I.G., Philips, M.A., Rutledge, G.A., Phung, K.H., Mueller, L.D., Greer, L.F. -- Development and aging : two opposite but complementary phenomena / Feltes, B.C., De Faria Poloni, J., Bonatto, D. -- Aging as a process of deficit accumulation : its utility and origin / Mitnitski, A., Rockwood, K. -- Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease / Guarner, V., Rubio-Ruiz, M.E. -- Modulating mTOR in aging and health / Johnson, S.C., Sangesland, M., Kaeberlein, M., Rabinovitch, P. -- Melatonin and circadian oscillators in aging : a dynamic approach to the multiply connected players / Hardeland, R. -- Diet-microbiota-health interactions in older subjects : implications for healthy aging / Lynch, D.B., Jeffery, I.B., Cusack, S., O'Connor, E.M., O'Toole, P.W. -- Systems biology approaches in aging research / Chauhan, A., Liebal, U.W., Vera, J., Baltrusch, S., Junghanss, C., Tiedge, M., Fuellen, G., Wolkenhauer, O., Ko?hling, R. -- Conservative growth hormone/IGF-1 and mTOR signaling pathways as a target for aging and cancer prevention : do we really have an antiaging drug? / Anisimov, V.N. 330 $aAging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. 410 0$aInterdisciplinary topics in gerontology ;$vv. 40. 606 $aAging$xPhysiological aspects 610 $aMedicine & Public Health 610 $aGerontology 610 $aGeriatrics 610 $aGenetics 610 $aBioinformatics 610 $aGenomics 610 $aPhysiology 610 $aMedicine 615 0$aAging$xPhysiological aspects. 676 $a612.6/7 700 $aYashin$b Anatoliy I$4edt$01061587 702 $aYashin$b Anatoli I. 702 $aJazwinski$b S. Michal 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910353342603321 996 $aAging and health$93361118 997 $aUNINA