LEADER 00807nam0 2200253 450 001 000001233 005 20050630115300.0 100 $a--------d1972----km-y0itay50------ba 101 $aita 102 $aIT 200 1 $aTeorie e ideologie nel diritto sindacale$el'esperienza italiana dopo la Costituzione$fGiovanni Tarello 205 $a2. ed. 210 $aMilano$cEdizioni di comunità$d1972 215 $a197 p.$d23 cm 225 2 $aDiritto e cultura moderna$v5 410 0$12001$aDiritto e cultura moderna 610 1 $aSindacati$aDiritto 676 $a331.88 700 1$aTarello,$bGiovanni$0142691 801 0$aIT $bUNIPARTHENOPE $gRICA $2UNIMARC 912 $a000001233 951 $cNAVA1$a344-T/1$b18278$d20000414 996 $aTeorie e ideologie nel diritto sindacale$9194549 997 $aUNIPARTHENOPE LEADER 01167nam--2200349---450- 001 990003312560203316 005 20090916121022.0 035 $a000331256 035 $aUSA01000331256 035 $a(ALEPH)000331256USA01 035 $a000331256 100 $a20090916d1984----km-y0itay50------ba 101 $aeng 102 $aIT 105 $ay---||||001yy 200 1 $aHourly values and graphycs of the geomagnetic variations at Capri station during the year 1980$fA. Galdi, A. Sposito, M. Vultaggio 210 $aNapoli$cIstituto Universitario Navale$d1984 215 $a5 p.$c23 tab.$d24 cm 300 $aAppendice n. 1 degli "Annali dell'Istituto Universitario Navale" 606 0 $aGeomagnetismo 676 $a538.79 700 1$aGALDI,$bA.$09036 701 1$aSPOSITO,$bA.$0333799 701 1$aVULTAGGIO,$bM.$09038 801 0$aIT$bsalbc$gISBD 912 $a990003312560203316 951 $a538.79 GAL$b9733/CBS$c538.79$d00327541 959 $aBK 969 $aSCI 979 $aRSIAV7$b90$c20090916$lUSA01$h1210 996 $aHourly values and graphycs of the geomagnetic variations at Capri station during the year 1980$91122236 997 $aUNISA LEADER 04119nam 22005415 450 001 9910350351903321 005 20200706081322.0 010 $a981-13-3540-0 024 7 $a10.1007/978-981-13-3540-2 035 $a(CKB)4100000008525765 035 $a(DE-He213)978-981-13-3540-2 035 $a(MiAaPQ)EBC5771251 035 $a(PPN)236519840 035 $a(EXLCZ)994100000008525765 100 $a20190506d2019 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDiabetes Mellitus $eA risk factor for Alzheimer's Disease /$fedited by Yusaku Nakabeppu, Toshiharu Ninomiya 205 $a1st ed. 2019. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019. 215 $a1 online resource (VI, 248 p. 49 illus., 28 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1128 311 $a981-13-3539-7 327 $aChapter 1 Origins of brain insulin and its function -- Chapter 2 Epidemiological evidence of the relationship between diabetes and dementia -- Chapter 3 Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer?s Disease Brain -- Chapter 4 The Full Spectrum of Alzheimer's Disease is Rooted in Metabolic -- Derangements That Drive Type 3 Diabetes -- Chapter 5 The roles of apolipoprotein E, lipids and glucose in the pathogenesis of Alzheimer?s disease -- Chapter 6 Molecular connection between diabetes and dementia -- Chapter 7 Type II Diabetes mellitus accelerates age-dependent A? pathology in cynomolgus monkey brain -- Chapter 8 Diabetes-related dementia -- Chapter 9 Tortuous paths of insulin signaling and mitochondria in Alzheimer's disease -- Chapter 10 Mammalian target of rapamycin at the crossroad between Alzheimer?s Disease and diabetes -- Chapter 11 Therapeutic strategies for Alzheimer?s disease in the view of diabetes mellitus. 330 $aThis book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer?s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1128 606 $aNeurosciences 606 $aDiabetes 606 $aNeurology 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aDiabetes$3https://scigraph.springernature.com/ontologies/product-market-codes/H33045 606 $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001 615 0$aNeurosciences. 615 0$aDiabetes. 615 0$aNeurology. 615 14$aNeurosciences. 615 24$aDiabetes. 615 24$aNeurology. 676 $a612.8 702 $aNakabeppu$b Yusaku$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aNinomiya$b Toshiharu$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910350351903321 996 $aDIABETES mellitus$9395225 997 $aUNINA