LEADER 04330nam  22006135  450 
001 9910350351003321
005 20200702153253.0
010   $a981-13-6260-2
024 7 $a10.1007/978-981-13-6260-6
035   $a(CKB)4100000009158733
035   $a(MiAaPQ)EBC5845098
035   $a(DE-He213)978-981-13-6260-6
035   $a(PPN)238486125
035   $a(EXLCZ)994100000009158733
100   $a20190731d2019      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAldehyde Dehydrogenases $eFrom Alcohol Metabolism to Human Health and Precision Medicine /$fedited by Jun Ren, Yingmei Zhang, Junbo Ge
205   $a1st ed. 2019.
210  1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019.
215   $a1 online resource (xx, 253 pages)
225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1193
311   $a981-13-6259-9 
320   $aIncludes bibliographical references.
327   $a1. Role of alcohol oxidative metabolism in its cardiovascular and autonomic effects -- 2. Environmental aldehyde sources and the health implications of exposure -- 3. ALDH2 and cardiovascular disease -- 4. Aldehyde dehydrogenases: From alcohol metabolism to human health and precision medicine -- 5. Aldehyde dehydrogenase 2 and heart Failure -- 6. Mitochondrial aldehyde dehydrogenase in myocardial ischemic and ischemia-reperfusion injury -- 7. East Asian variant aldehyde dehydrogenase 2 genotype (ALDH2*2*) contributes to coronary artery spasm and acute myocardial infarction -- 8. Aldehyde dehydrogenases genetic polymorphism and obesity: from genomics to behavior and health -- 9. Aldehyde dehydrogenase (ALDH) 2 in diabetic heart diseases -- 10. The role of ALDH2 in sepsis and the to-be-discovered mechanisms -- 11. ALDH2 and stroke -- 12. ALDH2 and hypertension -- 13. ALDH2 and cancer therapy -- 14. ALDH2 polymorphism and ethanol consumption: A genetic-environmental interaction in carcinogenesis -- 15. ALDH2 and aging.
330   $aThis volume covers the science of ALDH enzymes in relation to chronic disease processes and the future therapeutic potentials of targeting ALDH in these processes. It thoroughly reviews the roles of ALDH family in alcohol metabolism, as well as recent findings of their emerging roles in a variety of human pathologies such as cardiovascular diseases, diabetes, obesity, stroke, cancer, liver diseases and kidney diseases. Delicate contribution of ALDH enzymes in the therapeutics against chronic diseases is also discussed. It demonstrates the unique value of targeting genetic polymorphism in ALDH enzymes in personalized medicine. The book will appeal to scientists, physicians, graduate and professional students in the fields of ALDH enzymes, alcohol metabolism, cardiometabolic and other chronic diseases. Pharmaceutical and other companies developing new tools for cardiometabolic and chronic diseases treatment will also find this a valuable resource.
410  0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1193
606   $aMolecular biology
606   $aEnzymology
606   $aHuman physiology
606   $aMetabolism$xDisorders
606   $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
606   $aEnzymology$3https://scigraph.springernature.com/ontologies/product-market-codes/L14070
606   $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004
606   $aMetabolic Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33118
615  0$aMolecular biology.
615  0$aEnzymology.
615  0$aHuman physiology.
615  0$aMetabolism$xDisorders.
615 14$aMolecular Medicine.
615 24$aEnzymology.
615 24$aHuman Physiology.
615 24$aMetabolic Diseases.
676   $a612.0151
702   $aRen$b Jun$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aZhang$b Yingmei$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aGe$b Junbo$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910350351003321
996   $aAldehyde Dehydrogenases$92147598
997   $aUNINA