LEADER 01027cam0-22003371i-450- 001 990007382530403321 005 20070904112816.0 010 $a0-534-38931-7 035 $a000738253 035 $aFED01000738253 035 $a(Aleph)000738253FED01 035 $a000738253 100 $a20030110d2002----km-y0itay50------ba 101 0 $aeng 102 $aUS 105 $aa-------001yy 200 1 $aManagerial statistics$fS. Christian Albright, Wayne L. Winston, Christopher Zappe$gwith case studies by Peter Kolesar 210 $aPacific Grove$cDuxbury$dİ2002 215 $aXX, 937 p.$cill.$d26 cm$ecd-rom 610 0 $aManagement$aMetodi statistici 676 $a658.403$v21$zita 700 1$aAlbright,$bS. Christian$0145431 701 1$aWinston,$bWayne L.$0145432 701 1$aZappe,$bChristopher$0145433 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990007382530403321 952 $aVI E 1004$b38791$fFSPBC 959 $aFSPBC 996 $aManagerial statistics$9692704 997 $aUNINA LEADER 00650nam a2200217 i 4500 001 991004354033607536 005 20241129111551.0 008 931020s1959 it e 001 0 ita d 082 04$a320.54$223 082 04$a320.54096$223 100 1 $aHodgkin, Thomas$0209912 240 10$aNationalism in colonial Africa$930471 245 00$aNazionalismo nell'Africa coloniale /$cThomas Hodgkin 260 $aRoma :$bEditori riuniti,$cc1959 300 $a149 p. ;$c21 cm 490 1 $aNostro tempo 650 4$aNazionalismo$zAfrica 830 0$aNostro tempo 912 $a991004354033607536 996 $aNationalism in colonial Africa$930471 997 $aUNISALENTO LEADER 04101nam 22006135 450 001 9910350350303321 005 20251116220311.0 010 $a981-13-8958-6 024 7 $a10.1007/978-981-13-8958-0 035 $a(CKB)4100000009451822 035 $a(DE-He213)978-981-13-8958-0 035 $a(MiAaPQ)EBC5889016 035 $a(PPN)260305669 035 $a(EXLCZ)994100000009451822 100 $a20190831d2019 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aClinical Epigenetics /$fedited by Luke B. Hesson, Antonia L. Pritchard 205 $a1st ed. 2019. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019. 215 $a1 online resource (XI, 265 p. 34 illus., 8 illus. in color.) 311 08$a981-13-8957-8 327 $aGenetics and epigenetics: a Historical Overview -- The DNA methylation machinery -- Methylcytosine and its oxidised derivatives -- The role of nucleosomes in epigenetic gene regulation -- Circular RNAs in human health and disease -- The role of histone variants in cancer -- DNA methylation and carcinogenesis: Current and future perspectives -- Dysregulation of cis-regulatory elements in cancer -- Germline epigenetic testing of imprinting disorders in a diagnostic setting -- Cancer methylation biomarkers in circulating cell-free DNA -- The clinical utility of epigenetics. 330 $aIn genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing. 606 $aGene expression 606 $aMedical genetics 606 $aGene therapy 606 $aCytogenetics 606 $aMolecular biology 606 $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010 606 $aGene Function$3https://scigraph.springernature.com/ontologies/product-market-codes/B12030 606 $aGene Therapy$3https://scigraph.springernature.com/ontologies/product-market-codes/B12020 606 $aCytogenetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12040 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 615 0$aGene expression. 615 0$aMedical genetics. 615 0$aGene therapy. 615 0$aCytogenetics. 615 0$aMolecular biology. 615 14$aGene Expression. 615 24$aGene Function. 615 24$aGene Therapy. 615 24$aCytogenetics. 615 24$aMolecular Medicine. 676 $a611.01816 702 $aHesson$b Luke B.$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aPritchard$b Antonia L.$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910350350303321 996 $aClinical epigenetics$91908812 997 $aUNINA