LEADER 04268nam 22006015 450 001 9910350349703321 005 20200630194453.0 010 $a981-13-7647-6 024 7 $a10.1007/978-981-13-7647-4 035 $a(CKB)4100000009757358 035 $a(MiAaPQ)EBC5916284 035 $a(DE-He213)978-981-13-7647-4 035 $a(PPN)248602004 035 $a(EXLCZ)994100000009757358 100 $a20190930d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDrug Transporters in Drug Disposition, Effects and Toxicity$b[electronic resource] /$fedited by Xiaodong Liu, Guoyu Pan 205 $a1st ed. 2019. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019. 215 $a1 online resource (588 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1141 311 $a981-13-7646-8 327 $aOverview: role of drug transporters in drug disposition and its clinical significance -- ABC family transporters -- SLC family transporters -- Current research method in transporter study -- Transporter-mediated drug?drug interactions and their significance -- Roles of hepatic drug transporters in drug disposition and liver toxicity -- Roles of renal drug transporter in drug disposition and renal toxicity -- Intestinal transporter associated toxicity and absorption -- Contributions of drug transporters to blood-brain barriers -- Contributions of drug transporters to blood-retinal barrier(BRB) -- Contributions of drug transporters to blood-placental barrier -- ABC transporter-mediated multidrug-resistant cancer. 330 $aThis book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1141 606 $aPharmacology 606 $aPharmacy 606 $aMedicinal chemistry 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aDrug Safety and Pharmacovigilance$3https://scigraph.springernature.com/ontologies/product-market-codes/H69010 606 $aPharmacy$3https://scigraph.springernature.com/ontologies/product-market-codes/F00008 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 615 0$aPharmacology. 615 0$aPharmacy. 615 0$aMedicinal chemistry. 615 14$aPharmacology/Toxicology. 615 24$aDrug Safety and Pharmacovigilance. 615 24$aPharmacy. 615 24$aMedicinal Chemistry. 676 $a615.1 702 $aLiu$b Xiaodong$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aPan$b Guoyu$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910350349703321 996 $aDrug Transporters in Drug Disposition, Effects and Toxicity$92147596 997 $aUNINA