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035   $a(DE-He213)978-981-13-9913-8
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100   $a20191003d2019      u|         0
101 0 $aeng
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181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aNeuroglia in Neurodegenerative Diseases /$fedited by Alexei Verkhratsky, Margaret S. Ho, Robert Zorec, Vladimir Parpura
205   $a1st ed. 2019.
210  1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019.
215   $a1 online resource (x, 405 pages) $cillustrations
225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1175
311   $a981-13-9912-3 
327   $aIntroduction to neuroglia: history, definition, development and main functions -- Evolution of astroglia -- Physiology of astroglia -- Glicoryne system: glial cells as secretory cells of the CNS -- Physiology of oligodendroglia and NG-2 glia -- Physiology of microglia -- General pathophysiology of neuroglia -- Neuroglia in ageing -- In vivo imaging of neuroglia in neurodegenerative diseases -- Astroglia in leukodystrophies -- Astrocytes in ALS -- Astroglia in Alzheimer's disease -- Oligodendrogia in Alzheimer's disease -- Microglia in AD -- Neuroglia in Parkinson's disease -- Neuroglia in Huntington disease -- Neuroglia as a therapeutic target -- Stem cell derived neuroglia: new tool for research and treatment of neurodegenerative diseases.
330   $aThis book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer?s, Parkinson?s, and Huntington?s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.
410  0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1175
606   $aNeurosciences
606   $aNeurology 
606   $aMolecular biology
606   $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006
606   $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001
606   $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
615  0$aNeurosciences.
615  0$aNeurology .
615  0$aMolecular biology.
615 14$aNeurosciences.
615 24$aNeurology.
615 24$aMolecular Medicine.
676   $a616.8047
702   $aVerkhratsky$b Alexei$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aHo$b Margaret S$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aZorec$b Robert$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aParpura$b Vladimir$4edt$4http://id.loc.gov/vocabulary/relators/edt
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906   $aBOOK
912   $a9910350348703321
996   $aNeuroglia in Neurodegenerative Diseases$92140601
997   $aUNINA