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010   $a981-13-2402-6
024 7 $a10.1007/978-981-13-2402-4
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035   $a(DE-He213)978-981-13-2402-4
035   $a(EXLCZ)994100000006671787
100   $a20180914d2019      u|             0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aPatient-Specific Controller for an Implantable Artificial Pancreas$b[electronic resource] /$fby Yvonne  Ho
205   $a1st ed. 2019.
210  1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019.
215   $a1 online resource (97 pages)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
311   $a981-13-2401-8 
327   $aIntroduction -- Glucose Metabolism and Diabetes -- Literature Review -- Design of an Implantable Artificial Pancreas -- Model Predictive Controller using Interior Point and Ant Algorithm -- In Vivo Experiment of the Implantable Artificial Pancreas -- Parameter Estimation for Nonlinear Mathematical Model -- Conclusion and Future Work.
330   $aThe thesis focuses on the control of blood glucose devices and design of implantable devices, and offers valuable insights on diabetes mellitus and related physiology and treatments. Diabetes mellitus is a widespread chronic disease in the modern world that affects millions of people around the globe. In Singapore, one in ten of the population has diabetes, and the severity of the problem has prompted the country?s prime minister to talk about the disease at the National Day Rally in 2017. Designing an artificial pancreas that can provide effective blood glucose control for individuals with diabetes is one of the most challenging engineering problems. The author reports on research into the development of an implantable artificial pancreas that can regulate blood glucose levels by delivering appropriate dosages of insulin when necessary. By sensing blood glucose and injecting insulin directly into the vein, the implantable device aims to remove delays that occur with subcutaneous blood glucose sensing and insulin delivery. Preliminary in-vitro and in-vivo experimental results suggest that the implantable device for blood glucose control could be a clinically viable alternative to pancreas transplant.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
606   $aBiomedical engineering
606   $aDiabetes
606   $aBiomedical Engineering and Bioengineering$3http://scigraph.springernature.com/things/product-market-codes/T2700X
606   $aBiomedical Engineering/Biotechnology$3http://scigraph.springernature.com/things/product-market-codes/B24000
606   $aDiabetes$3http://scigraph.springernature.com/things/product-market-codes/H33045
606   $aControl and Systems Theory$3http://scigraph.springernature.com/things/product-market-codes/T19010
615  0$aBiomedical engineering.
615  0$aDiabetes.
615 14$aBiomedical Engineering and Bioengineering.
615 24$aBiomedical Engineering/Biotechnology.
615 24$aDiabetes.
615 24$aControl and Systems Theory.
676   $a616.462025
700   $aHo$b Yvonne $4aut$4http://id.loc.gov/vocabulary/relators/aut$0871313
906   $aBOOK
912   $a9910350312903321
996   $aPatient-Specific Controller for an Implantable Artificial Pancreas$91945079
997   $aUNINA