LEADER 04628nam 22005535 450 001 9910350223303321 005 20200630133122.0 010 $a981-13-8433-9 024 7 $a10.1007/978-981-13-8433-2 035 $a(CKB)4100000009158772 035 $a(MiAaPQ)EBC5855461 035 $a(DE-He213)978-981-13-8433-2 035 $a(PPN)248600028 035 $a(EXLCZ)994100000009158772 100 $a20190820d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aIn Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials /$fedited by Toru Takebayashi, Robert Landsiedel, Masashi Gamo 205 $a1st ed. 2019. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019. 215 $a1 online resource (221 pages) 225 1 $aCurrent Topics in Environmental Health and Preventive Medicine,$x2364-8333 311 $a981-13-8432-0 327 $a1 The role of in vivo screening studies in assessing manufactured nanomaterials -- Part 1 Short Term Inhalation Study -- 2. The short-term inhalation study (STIS) as a range finder and screening tool in a tiered grouping strategy -- 3. Use of short-term inhalation study to obtain initial hazard data and prepare for subacute and subchronic inhalation studies, and toxicokinetic studies -- 4. Subchronic inhalation Toxicity Study with a Vapor Grown Carbon Nanofiber in Male and Female Rats (OECD 413) ? Does nanofiber exposure have adverse impacts on the cardiovascular system? -- Part 2 Intratracheal Administration Study -- 5. Comparison of responses in rat lung following inhalation and intratracheal administration of nanoparticles -- 6. Standardization of intratracheal instillation study of manufactured nanomaterials -- 7. Sample preparation and the chracterization for Intratracheal Administration -- 8. Development of intra-tracheal intra-pulmonary spraying (TIPS) as an alternative assay method for testing chronic toxicity and carcinogenic potential of multiwall carbon nanotubes -- 9. Equivalence Criteria for Nanomaterials Developed from Results of a Comparative Study using Intratracheal Administration -- 10. Toxicokinetics of nano materials after the intratracheal administration -- 11. In Vitro Alveolar Epithelial Models toward the Prediction of Cytotoxicity Tests and Translocation Studies of Nanoparticles. . 330 $aThis edited volume discusses the short-term inhalation study (STIS) and intratracheal administration, the two major in vivo inhalation-toxicity screening methods, which play an important role in efficient hazard evaluation. It also provides a general overview of the inhalation toxicity of nanomaterials and related issues. For each screening method, it provides up-to-date information on the test procedures, interpretation of the test results, useful applications, and related technologies. In view of the increasing variety of nanomaterials in practical use, the book offers a basis for building a framework for grouping and read-across assessments of nanomaterials. With contributions by academic and industrial experts, In vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials is a pragmatic reference resource for readers who are responsible for assessing the safety of nanomaterials in R&D and business, as well as researchers. 410 0$aCurrent Topics in Environmental Health and Preventive Medicine,$x2364-8333 606 $aHealth promotion 606 $aHealth administration 606 $aPharmacology 606 $aHealth Promotion and Disease Prevention$3https://scigraph.springernature.com/ontologies/product-market-codes/H27010 606 $aHealth Administration$3https://scigraph.springernature.com/ontologies/product-market-codes/H27030 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 615 0$aHealth promotion. 615 0$aHealth administration. 615 0$aPharmacology. 615 14$aHealth Promotion and Disease Prevention. 615 24$aHealth Administration. 615 24$aPharmacology/Toxicology. 676 $a338.476205 702 $aTakebayashi$b Toru$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aLandsiedel$b Robert$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGamo$b Masashi$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910350223303321 996 $aIn Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials$91736169 997 $aUNINA