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101 0 $aeng
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181   $ctxt$2rdacontent
182   $cc$2rdamedia
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200 10$aProteomic and Ionomic Study for Identification of Biomarkers in Biological Fluid Samples of Patients with Psychiatric Disorders and Healthy Individuals /$fby Jemmyson Romário de Jesus
205   $a1st ed. 2019.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019.
215   $a1 online resource (108 pages)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
300   $a"Doctoral thesis accepted by the University of Campinas, Campinas, Brazil"--Title page.
311   $a3-030-29472-2 
327   $aIntroduction -- Application of a Proteomic Strategy for the Identification of Differential Proteins Candidates to Biomarkers of Bipolar Disorder -- Application of the Ionomic Strategy to Evaluate Possible Differences in Metal Ion Concentration Between Patients with Bipolar Disorder and other Psychiatric Disorders -- Development of a New Polymer Membrane Based Methodology for Characterization of the Urine Proteome -- Final Conclusion. .
330   $aThis book presents an exploratory analysis based on proteomic and ionomics studies comparing the blood serum of patients with bipolar disorder (BD), healthy controls, patients with schizophrenia (SCZ), and patients with other disorders (OD) in order to identify biomarkers of BD. Bipolar disorder is a psychiatric condition that affects thousands of people worldwide. The absence of biomarkers for BD has resulted in misdiagnosis and ineffective treatment in some patients, causing additional health problems and high costs for health systems. As such, this book evaluates various strategies for sample preparation for proteomic and ionomic studies in order to simplify complex serum samples and allow the quantification of chemical species (proteins and metal ions), which are potential candidates for BD biomarkers. In addition, it describes the development of a new membrane-based methodology for extracting urine proteins to be used in biomarker discovery.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
606   $aAnalytical chemistry
606   $aPsychobiology
606   $aProteomics
606   $aPharmaceutical chemistry
606   $aAnalytical Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C11006
606   $aBiological Psychology$3https://scigraph.springernature.com/ontologies/product-market-codes/Y20020
606   $aProteomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L1403X
606   $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000
615  0$aAnalytical chemistry.
615  0$aPsychobiology.
615  0$aProteomics.
615  0$aPharmaceutical chemistry.
615 14$aAnalytical Chemistry.
615 24$aBiological Psychology.
615 24$aProteomics.
615 24$aMedicinal Chemistry.
676   $a610.28
676   $a610.28
700   $ade Jesus$b Jemmyson Romário$4aut$4http://id.loc.gov/vocabulary/relators/aut$01057900
801  0$bMiAaPQ
801  1$bMiAaPQ
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906   $aBOOK
912   $a9910349504303321
996   $aProteomic and Ionomic Study for Identification of Biomarkers in Biological Fluid Samples of Patients with Psychiatric Disorders and Healthy Individuals$92495405
997   $aUNINA