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024 7 $a10.1007/978-981-13-0593-1
035   $a(CKB)4100000009158603
035   $a(MiAaPQ)EBC5440563
035   $a(DE-He213)978-981-13-0593-1
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100   $a20180628d2018      u|         0
101 0 $aeng
135   $aurnn#008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aChromosome Translocation /$fedited by Yu Zhang
205   $a1st ed. 2018.
210  1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2018.
215   $a1 online resource (V, 168 p. 29 illus., 27 illus. in color.)
225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1044
311 08$a981-13-0592-7 
327   $aChapter 1: Historical and clinical overview of chromosome translocations -- Chapter 2: Next generation sequencing to identify chromosome translocation -- Chapter 3: The experimental models to study chromosome translocations -- Chapter 4: High throughput translocation sequencing to identify mechanistic factors shaping translocatome -- Chapter 5: Live cell imaging to study chromosome translocation -- Chapter 6: CRISPR/Cas9 to induce chromosome translocation in vivo -- Chapter 7: Generation of DNA double strand breaks (DSBs) -- Chapter 8: The role of DSB response pathway in regulating chromosome translocation -- Chapter 9: DSB repair and ligation of chromosome translocation -- Chapter 10: 3D genome organization defines the chromosome translocation pattern -- Chapter 11: Mechanisms of chromosome deletion -- Chapter 12: Chromothripsis: The role of DNA double strand break form on repair pathway selection.
330   $aThis volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases. The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation. It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases.
410  0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1044
606   $aHuman genetics
606   $aCytology
606   $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
615  0$aHuman genetics.
615  0$aCytology.
615 14$aHuman Genetics.
615 24$aCell Biology.
676   $a611.01816
676   $a599.935
702   $aZhang$b Yu$c(Of National Institute of Biological Sciences)$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910349476303321
996   $aChromosome Translocation$92529411
997   $aUNINA