LEADER 03023nam 22005415 450 001 9910349470503321 005 20200702151003.0 010 $a981-13-1071-8 024 7 $a10.1007/978-981-13-1071-3 035 $a(CKB)4100000009158623 035 $a(MiAaPQ)EBC5507735 035 $a(DE-He213)978-981-13-1071-3 035 $a(PPN)230534783 035 $a(EXLCZ)994100000009158623 100 $a20180903d2018 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aApplied Computational Genomics /$fedited by Yin Yao 205 $a2nd ed. 2018. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2018. 215 $a1 online resource (VII, 150 p. 14 illus., 13 illus. in color.) 225 1 $aTranslational Bioinformatics,$x2213-2775 ;$v13 311 $a981-13-1070-X 327 $aIntroduction -- Exploring Polygenic Overlap Between ADHD and OCD -- Concepts of Genetic Epidemiology -- Rare Variants Analysis in Unrelated Individuals -- Whole Genome Association of Treatment Response in OCD -- QTL Mapping of Molecular Traits for Studies of Human Complex Diseases -- From Family Study to Population Study: A History of Genetic Mapping for Nasopharyngeal Carcinoma (NPC) -- Test for Nonlinear Dependence of Two Continuous Variables -- Analytical Approaches for Exome Sequence Data -- Machine Learning Approaches: Data Integration for Disease Prediction and Prognosis -- OCD Genomics and Future Looks. 330 $aThe volume provides a review of statistical development and application in the area of human genomics, including candidate gene mapping, linkage analysis, population-based genome-wide association, exon sequencing, and whole genome sequencing analysis. The authors are extremely experienced in the field of statistical genomics and will give a detailed introduction to the evolution of the field, as well as critical comments on the advantages and disadvantages of the proposed statistical models. The future directions of translational biology will also be described. 410 0$aTranslational Bioinformatics,$x2213-2775 ;$v13 606 $aHuman genetics 606 $aBioinformatics 606 $aBiotechnology 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aBioinformatics$3https://scigraph.springernature.com/ontologies/product-market-codes/L15001 606 $aBiotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/C12002 615 0$aHuman genetics. 615 0$aBioinformatics. 615 0$aBiotechnology. 615 14$aHuman Genetics. 615 24$aBioinformatics. 615 24$aBiotechnology. 676 $a611.01816 676 $a599.935 702 $aYao$b Yin$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910349470503321 996 $aApplied Computational Genomics$92528874 997 $aUNINA