LEADER 04385nam 22006015 450 001 9910349465503321 005 20200702142041.0 010 $a981-13-6186-X 024 7 $a10.1007/978-981-13-6186-9 035 $a(CKB)4100000008876686 035 $a(MiAaPQ)EBC5741259 035 $a(DE-He213)978-981-13-6186-9 035 $a(PPN)235230286 035 $a(EXLCZ)994100000008876686 100 $a20190325d2019 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aProgranulin and Central Nervous System Disorders /$fedited by Hideaki Hara, Masato Hosokawa, Shinsuke Nakamura, Takayoshi Shimohata, Masugi Nishihara 205 $a1st ed. 2019. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019. 215 $a1 online resource (VII, 183 p. 37 illus., 13 illus. in color.) 311 $a981-13-6185-1 327 $aChapter 1. Molecular and Functional Properties of Progranulin -- Chapter 2. Progranulin as a biomarker for neurodegenerative diseases -- Chapter 3. PGRN and FTLD -- Chapter 4. PGRN and neurodegenerative diseases other than FTLD -- Chapter 5. Progranulin Regulations of Lysosomal Homeostasis and its Involvement in Neurodegenerative Diseases -- Chapter 6. Molecular and Functional Properties of Progranulin -- Chapter 7. PGRN and neuroinflammation -- Chapter 8. Neural Stem/Progenitor Cells and Progranulin -- Chapter 9. Generation and phenotyping of progranulin-deficient mice -- Chapter 10. Pleiotropic protective effects of progranulin in the treatment of ischemic stroke -- Chapter 11. New therapeutic approaches against ocular diseases. 330 $aThis book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students. 606 $aMedical genetics 606 $aMolecular biology 606 $aProteins 606 $aNeurosciences 606 $aGene Function$3https://scigraph.springernature.com/ontologies/product-market-codes/B12030 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 615 0$aMedical genetics. 615 0$aMolecular biology. 615 0$aProteins. 615 0$aNeurosciences. 615 14$aGene Function. 615 24$aMolecular Medicine. 615 24$aProtein Science. 615 24$aNeurosciences. 676 $a611.01816 702 $aHara$b Hideaki$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHosokawa$b Masato$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aNakamura$b Shinsuke$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aShimohata$b Takayoshi$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aNishihara$b Masugi$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910349465503321 996 $aProgranulin and Central Nervous System Disorders$92140599 997 $aUNINA