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010   $a3-030-21664-0
024 7 $a10.1007/978-3-030-21664-1
035   $a(CKB)4100000008702203
035   $a(MiAaPQ)EBC5826037
035   $a(DE-He213)978-3-030-21664-1
035   $a(PPN)238486222
035   $a(EXLCZ)994100000008702203
100   $a20190712d2019      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aEpigenesis, Genetic /$fedited by Elisabetta Baldi, Monica Muratori
205   $a2nd ed. 2019.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019.
215   $a1 online resource (216 pages)
225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1166
311   $a3-030-21663-2 
320   $aIncludes bibliographical references.
327   $aGenetic factors affecting sperm chromatin structure -- Mechanisms of origin of chromosome deletions and rearrangements in spermatozoa -- The sperm epigenome: implications for ART outcomes -- Epigenetic transgenerational inheritance -- Environmental genetic and epigenetic sperm alterations -- Sperm DNA fragmentation: mechanisms of origin -- Sperm DNA fragmentation: consequences for reproduction -- Oxidative damage to sperm DNA: attack and defence -- Interventions to prevent sperm DNA damage effects on reproduction.-Cryopreservation of sperm: effects on chromatin and strategies to prevent them -- Effect on sperm DNA quality following sperm selection for ART: new insights -- Sperm DNA damage in cancer patients -- Index.
330   $aThere are several types of damage that can be found in the male gamete. This book covers the genetic damage in spermatozoa that can originate during spermatogenesis, or during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.
410  0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1166
606   $aGene expression
606   $aMedical genetics
606   $aHuman physiology
606   $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010
606   $aGene Function$3https://scigraph.springernature.com/ontologies/product-market-codes/B12030
606   $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004
615  0$aGene expression.
615  0$aMedical genetics.
615  0$aHuman physiology.
615 14$aGene Expression.
615 24$aGene Function.
615 24$aHuman Physiology.
676   $a573.21
676   $a571.93845
702   $aBaldi$b Elisabetta$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aMuratori$b Monica$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910349454403321
996   $aEpigenesis, Genetic$92568899
997   $aUNINA