LEADER 01024nam a2200253 i 4500 001 991000313459707536 005 20020506125111.0 008 960311s1989 it ||| | ita 035 $ab10683033-39ule_inst 035 $aEXGIL143349$9ExL 040 $aDip.to Filol. Ling. e Lett.$bita 100 1 $aBuratta, Vittoria$0533825 245 10$aTecniche di somministrazione del questionario /$c[Vittoria Buratta, Linda Laura Sabbadini] 260 $a[Roma] :$bIstat,$c1989 300 $a70 p. ;$c26 cm. 490 0 $aManuale di tecniche di indagine ;$v3 650 4$aIstat$zRoma$y1989 700 1 $aSabbadini, Linda Laura$eauthor$4http://id.loc.gov/vocabulary/relators/aut$0147919 907 $a.b10683033$b23-02-17$c28-06-02 912 $a991000313459707536 945 $aLE008 FL.M. SCL A 14/1$g1$i2008000454616$lle008$o-$pE0.00$q-$rl$s- $t0$u1$v2$w1$x0$y.i10776746$z28-06-02 996 $aTecniche di somministrazione del questionario$91455206 997 $aUNISALENTO 998 $ale008$b01-01-96$cm$da $e-$fita$git $h0$i1 LEADER 03869nam 22004695 450 001 9910349452403321 005 20200702011159.0 010 $a3-030-17148-5 024 7 $a10.1007/978-3-030-17148-3 035 $a(CKB)4100000008747473 035 $a(MiAaPQ)EBC5838945 035 $a(DE-He213)978-3-030-17148-3 035 $a(PPN)23849151X 035 $a(EXLCZ)994100000008747473 100 $a20190724d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEndotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems /$fedited by Kevin L. Williams 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (865 pages) 311 $a3-030-17147-7 327 $aIntroduction -- Section I Pharma -- Historical Perspectives -- Risk, Control and Compliance. -- Sterility and Beyond -- LVPs and SMDs -- Specification Determination -- Static and Dynamic Models (Biodiversity and Heterogeneity) -- Test Development and Validation -- Diminishing Analytics -- Control in Biologics Manufacture -- Depyrogenation and Medical Devices -- Nanoparticles / Problematic Drug Types -- New Frontiers -- Section II Limulus -- Evolution, a Living Fossil and Other Model Arthropods -- Water, Water Everywhere -- Survival and Mass Extinction Events -- Limulus Soup / Hemolymph -- Is Innate Modeling Enough? -- A Foreboding -- Section III Mammalian -- Innate is Inborn -- The Host Response: Fever and Inflammation -- . Parallel Immune Systems: Architecture and Mechanisms -- Structural Change is Functional Change (Hand in Glove) -- Endotoxin and Adjuvanticity in Vaccinology -- Advances in Diagnostics -- The Big S. 330 $aEndotoxin detection and control is a dynamic area of applied science that touches a vast number of complex subjects. The intersection of test activities includes the use of an ancient blood system from an odd ?living fossil? (Limulus). It is used to detect remnants of the most primitive and destructive forms of life (prokaryotes) as contaminants of complex modern systems (mammalian and Pharma). Recent challenges in the field include those associated with the application of traditional methods to new types of molecules and manufacturing processes. The advent of ?at will? production of biologics in lieu of harvesting animal proteins has revolutionized the treatment of disease. While the fruits of the biotechnology revolution are widely acknowledged, the realization of the differences in the means of production and changes in the manner of control of potential impurities and contaminants in regard to the new versus the old are less widely appreciated. Endotoxin as an ancient, dynamic interface between lifeforms, provides a singular perspective from which to view the parallel development of ancient and modern organisms as well as the progress of man in deciphering the complexity of their interactions in his efforts to overcome disease. 606 $aPharmaceutical technology 606 $aMedical microbiology 606 $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010 606 $aMedical Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B16003 615 0$aPharmaceutical technology. 615 0$aMedical microbiology. 615 14$aPharmaceutical Sciences/Technology. 615 24$aMedical Microbiology. 676 $a599 676 $a615.95293 702 $aWilliams$b Kevin L$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910349452403321 996 $aEndotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems$92212308 997 $aUNINA