LEADER 02811nam  22004935  450 
001 9910349445703321
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010   $a981-329-267-9
024 7 $a10.1007/978-981-32-9267-3
035   $a(CKB)4100000009152993
035   $a(MiAaPQ)EBC5889019
035   $a(DE-He213)978-981-32-9267-3
035   $a(PPN)242824277
035   $a(EXLCZ)994100000009152993
100   $a20190830d2019      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aSIRT6 Activities in DNA Damage Repair and Premature Aging $eFunctions of SIRT6 /$fby Shrestha Ghosh
205   $a1st ed. 2019.
210  1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2019.
215   $a1 online resource (188 pages)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
300   $a"Doctoral thesis accepted by The University of Hong Kong, Hong Kong, China"--Title page.
311   $a981-329-266-0 
327   $aIntroduction -- Materials and Methods -- Results-I. Lamin A is an endogenous activator of SIRT6 in DNA damage repair process -- Results-II. Haploinsufficiency of p53 rescues lifespan and premature aging-associated abnormalities in Sirt6-deficient mice -- Results-III. SIRT6 is an acetylated protein and a NAD+-dependent self-deacetylase -- Discussion.
330   $aThis book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging. It mainly presents research on the nuclear lamin A, notably the upregulation of p53 and acetylation etc. Taken together, these studies reveal the various regulatory roles of SIRT6, which are of substantial biological relevance in DNA damage repair, aging and longevity, and can have significant implications in devising therapeutic strategies to combat age-associated pathologies. Given its scope, the book offers a valuable resource for students and researchers in the fields of genetics, cell biology, molecular biology etc.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
606   $aHuman genetics
606   $aCell biology
606   $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
615  0$aHuman genetics.
615  0$aCell biology.
615 14$aHuman Genetics.
615 24$aCell Biology.
676   $a572.86459
700   $aGhosh$b Shrestha$4aut$4http://id.loc.gov/vocabulary/relators/aut$0963288
906   $aBOOK
912   $a9910349445703321
996   $aSIRT6 Activities in DNA Damage Repair and Premature Aging$92184141
997   $aUNINA