LEADER 04563nam 22005895 450 001 9910349444803321 005 20200702145537.0 010 $a3-030-21162-2 024 7 $a10.1007/978-3-030-21162-2 035 $a(CKB)4100000009191091 035 $a(DE-He213)978-3-030-21162-2 035 $a(MiAaPQ)EBC5894527 035 $a(PPN)257359680 035 $a(EXLCZ)994100000009191091 100 $a20190909d2019 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBioactive Ceramides in Health and Disease$b[electronic resource] $eIntertwined Roles of Enigmatic Lipids /$fedited by Johnny Stiban 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (XII, 153 p. 31 illus., 14 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1159 311 $a3-030-21161-4 320 $aIncludes bibliographical references and index. 327 $aPreface -- About the Editor -- Introduction: Enigmas of Sphingolipids -- Prokaryotic and Mitochondrial Lipids: A Survey of Evolutionary Origins -- Ceramide Channels -- A Stroll Down the CerS Lane -- The Role of Ceramide 1-Phosphate in Inflammation, Cellular Proliferation, and Wound Healing -- Ceramide Domains in Health and Disease: a Biophysical Perspective -- Sphingolipids as Biomarkers of Disease -- Inflammatory Ocular Diseases and Sphingolipid Signaling -- Index. 330 $aThis book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented. Many aspects of ceramide and sphingolipid biology are addressed in this book. Its focus is the metabolism of ceramide in normal and diseased states and the biophysical and biochemical mechanisms governing the bioactivity of these molecules. Sphingolipid research has surged over the past thirty years and this book gathers the recent findings of various aspects of sphingolipid biochemistry. World-renowned scientists from the field of lipid biology, specifically sphingolipid biochemistry, were gathered to write this book. Scholars from most continents of the globe committed to write diligently about their expertise and the newest findings in the relevant fields. This book came to fruition after almost a year and a half of laborious preparation and diligent writings. This book is targeted to the experienced reader who is looking to read about the various aspects of bioactive ceramide signaling, as well as to the newcomer into the field, as the topics are explained in concise yet very informative manner. The authors and editor wish all readers a pleasant time reading this volume, and are adamant that this book will meet all expectations. . 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1159 606 $aMolecular biology 606 $aLipids 606 $aCancer research 606 $aBiomedical engineering 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aLipidology$3https://scigraph.springernature.com/ontologies/product-market-codes/L14080 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aBiomedical Engineering/Biotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/B24000 615 0$aMolecular biology. 615 0$aLipids. 615 0$aCancer research. 615 0$aBiomedical engineering. 615 14$aMolecular Medicine. 615 24$aLipidology. 615 24$aCancer Research. 615 24$aBiomedical Engineering/Biotechnology. 676 $a611.01816 702 $aStiban$b Johnny$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910349444803321 996 $aBioactive Ceramides in Health and Disease$92022552 997 $aUNINA