LEADER 04118nam 22006375 450 001 9910349443703321 005 20201206131731.0 010 $a3-030-23629-3 024 7 $a10.1007/978-3-030-23629-8 035 $a(CKB)4100000009273720 035 $a(DE-He213)978-3-030-23629-8 035 $a(MiAaPQ)EBC5896958 035 $a(PPN)248601970 035 $a(EXLCZ)994100000009273720 100 $a20190913d2019 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe Drosophila Model in Cancer /$fedited by Wu-Min Deng 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (VI, 250 p. 56 illus., 55 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1167 300 $aIncludes index. 311 $a3-030-23628-5 327 $aPrelims -- Drosophila model in cancer: an introduction -- Using Drosophila models and tools to understand the mechanisms of novel human cancer driver gene function -- The initial stage of tumorigenesis in Drosophila epithelial tissuesi -- Drosophila models of cell polarity and cell competition in tumourigenesis -- Two sides of the same coin ? compensatory proliferation in regeneration and cancer -- P53 and apoptosis in the Drosophila model -- Autophagy and tumorigenesis in Drosophila -- Filling the gaps among obesity, the CDK8 module, and uterine tumors using Drosophila -- MicroRNAs in Drosophila cancer models -- Cancer Stem Cells and Stem Cell Tumors in Drosophila -- Drosophila as a model for tumor-induced organ wasting -- Drosophila melanogaster as a model system for human glioblastomas -- What Drosophila Can Teach Us About Radiation Biology of Human Cancers -- Drosophila based cancer drug discovery frameworkIn -- Index. 330 $aThis volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model?s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1167 606 $aCancer research 606 $aMolecular biology 606 $aCell biology 606 $aBiomedical engineering 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aBiomedical Engineering/Biotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/B24000 615 0$aCancer research. 615 0$aMolecular biology. 615 0$aCell biology. 615 0$aBiomedical engineering. 615 14$aCancer Research. 615 24$aMolecular Medicine. 615 24$aCell Biology. 615 24$aBiomedical Engineering/Biotechnology. 676 $a614.5999 676 $a616.994027 702 $aDeng$b Wu-Min$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910349443703321 996 $aThe Drosophila Model in Cancer$91994003 997 $aUNINA