LEADER 04354nam 22006495 450 001 9910349442303321 005 20200715214044.0 010 $a3-030-22907-6 024 7 $a10.1007/978-3-030-22907-8 035 $a(CKB)4100000009382571 035 $a(DE-He213)978-3-030-22907-8 035 $a(MiAaPQ)EBC5927961 035 $a(PPN)260303968 035 $a(EXLCZ)994100000009382571 100 $a20190924d2019 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHuman Epigenetics: How Science Works /$fby Carsten Carlberg, Ferdinand Molnár 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (XVI, 153 p. 69 illus. in color.) 311 $a3-030-22906-8 327 $aIntroduction -- Chromatin and gene expression -- DNA methylation -- Histone modifications -- Chromatin modifying proteins and RNAs -- Embryogenesis and cellular differentiation -- Population epigenetics and aging -- Cancer epigenetics -- Neuroepigenetics -- Nutritional epigenetics -- Epigenetics of immune function -- Epigenome-environment interactions and their therapy. 330 $aThe view ?It?s all in our genes and we cannot change it? developed in the past 150 years since Gregor Mendel?s experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and are able to prevent the onset of diseases, such a type 2 diabetes or cancer. This book provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells forming our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described. The book represents an updated but simplified version of our textbook ?Human Epigenomics? (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease. 606 $aGene expression 606 $aMolecular biology 606 $aNutrition    606 $aCancer research 606 $aImmunology 606 $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aNutrition$3https://scigraph.springernature.com/ontologies/product-market-codes/C18000 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 615 0$aGene expression. 615 0$aMolecular biology. 615 0$aNutrition   . 615 0$aCancer research. 615 0$aImmunology. 615 14$aGene Expression. 615 24$aMolecular Medicine. 615 24$aNutrition. 615 24$aCancer Research. 615 24$aImmunology. 676 $a573.21 700 $aCarlberg$b Carsten$4aut$4http://id.loc.gov/vocabulary/relators/aut$0849346 702 $aMolnár$b Ferdinand$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910349442303321 996 $aHuman Epigenetics: How Science Works$92184138 997 $aUNINA