LEADER 04076nam 22006375 450 001 9910349440803321 005 20200630064326.0 010 $a3-030-26780-6 024 7 $a10.1007/978-3-030-26780-3 035 $a(CKB)4100000009522889 035 $a(DE-He213)978-3-030-26780-3 035 $a(MiAaPQ)EBC5940300 035 $a(PPN)248604481 035 $a(EXLCZ)994100000009522889 100 $a20191010d2019 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aFerroptosis in Health and Disease$b[electronic resource] /$fedited by Daolin Tang 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (VI, 324 p. 36 illus., 35 illus. in color.) 311 $a3-030-26779-2 327 $aLipid metabolism and ferroptosis -- 2. Iron metabolism and ferroptosis -- 3. Regulation and Function of Autophagy During Ferroptosis -- 4.Heat Shock Proteins: Endogenous Modulators of Ferroptosis -- 5. Biological Aspects of Endoplasmic Reticulum Stress in Ferroptosis -- 6. Gpx4 in ferroptosis -- 7. ACSL4 as the First Reliable Biomarker of Ferroptosis Under Pathophysiological Conditions -- 8. Regulation of Ferroptosis by MicroRNAs -- 9. Ferroptosis in Cardiovascular Disease -- 10. Ferroptosis in Nervous System Diseases -- 11. Regulation of Ferroptosis Through the Cysteine-Glutathione Redox Axis -- 12. Iron-Sulfur Cluster Metabolism Impacts Iron Homeostasis, Ferroptosis Sensitivity, and Human Disease -- 13. Ferroptosis in Liver Disease -- 14. p53 and Ferroptosis -- 15. Ferroptosis in Hemolytic Disorders -- 16. Lipoxygenase in Ferroptosis -- 17. Ferroptosis in Cancer Disease -- 18. Ferroptosis in Cancer Therapy. 330 $aThis book sheds new light on ferroptosis, as an only recently recognised form of regulated cell death. Its respective chapters address the numerous implications that ferroptosis can have for virtually all aspects of metabolism. They also share insights on the morphological characterisation of ferroptosis and highlight the different pathways of induction. Accordingly, the book offers a unique perspective on a mechanism that is involved in a multitude of pathologies, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, tissue ischemia/reperfusion injury, and T cell immunity. Readers will learn in which cell types this form of regulated cell death is likely to occur, and how it can be pharmacologically influenced, making the book a fascinating and informative read not only for scientists working in cell biology, but also for clinicians in the field of cancer research. . 606 $aCell physiology 606 $aApoptosis 606 $aHuman physiology 606 $aProteins  606 $aOxidative stress 606 $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010 606 $aApoptosis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16060 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aOxidative Stress$3https://scigraph.springernature.com/ontologies/product-market-codes/L16070 615 0$aCell physiology. 615 0$aApoptosis. 615 0$aHuman physiology. 615 0$aProteins . 615 0$aOxidative stress. 615 14$aCell Physiology. 615 24$aApoptosis. 615 24$aHuman Physiology. 615 24$aProtein Science. 615 24$aOxidative Stress. 676 $a571.6 702 $aTang$b Daolin$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910349440803321 996 $aFerroptosis in Health and Disease$92280555 997 $aUNINA