LEADER 03349nam 22005415 450 001 9910349439103321 005 20220309190043.0 010 $a3-030-27480-2 024 7 $a10.1007/978-3-030-27480-1 035 $a(CKB)4100000009678253 035 $a(MiAaPQ)EBC5969426 035 $a(DE-He213)978-3-030-27480-1 035 $a(PPN)258860332 035 $a(EXLCZ)994100000009678253 100 $a20191031d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBrain Glycogen Metabolism /$fedited by Mauro DiNuzzo, Arne Schousboe 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (viii, 443 pages) $cillustrations 225 1 $aAdvances in Neurobiology,$x2190-5215 ;$v23 311 $a3-030-27479-9 327 $a1. Introduction or Preface -- 2. Structure and regulation of glycogen synthase in the brain -- 3. Structure and regulation of glycogen phosphorylase in the brain -- 4. Regional distribution of glycogen in the brain -- 5. Metabolism of glycogen in the brain white matter -- 6. Metabolism of glycogen in the brain gray matter -- 7. Contribution of glycogen to brain energy metabolism -- 8. Brain glycogen, compartmentation and ion/transmitter homeostasis -- 9. Role of brain glycogen in learning and memory -- 10. Brain glycogen content and turnover during sleep-wake cycle -- 11. Brain glycogen metabolism in response to exercise -- 12. Brain glycogen metabolism in neuronal excitability and epilepsy -- 13. Brain glycogen metabolism in hypoglycemia and diabetes. . 330 $aThis book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular neurophysiology remains largely unclear and its specific contribution to the energy demand of brain cells is still elusive.Glycogen is the sole cerebral glucose reserve and is emerging as a fundamental component of brain energy metabolism. Pharmacological or genetic manipulation of glycogen metabolism in the brain impairs memory formation and increases susceptibility to epileptic seizures and cortical spreading depression. Glycogen is also directly implicated in abnormal neuronal excitability and mental retardation that characterize brain disorders like Lafora disease and Pompe disease. . 410 0$aAdvances in Neurobiology,$x2190-5215 ;$v23 606 $aNeurosciences 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aGlicogen$2thub 606 $aNeurociències$2thub 608 $aLlibres electrònics$2thub 615 0$aNeurosciences. 615 14$aNeurosciences. 615 7$aGlicogen 615 7$aNeurociències. 676 $a612.396 702 $aDiNuzzo$b Mauro$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSchousboe$b Arne$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910349439103321 996 $aBrain Glycogen Metabolism$91995454 997 $aUNINA