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035   $a(DE-He213)978-3-642-27728-3
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100   $a20190617d2020      u|             0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
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200 10$aDrug Discovery and Evaluation: Pharmacological Assays$b[electronic resource] /$fedited by Franz J. Hock
210  1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2020.
215   $a1 online resource (LVIII, 2071 p. 5 illus.) 
330   $aThe rapid progress in biology will continue to change the methodological approach to drug discovery in the coming years. Electronic media will continuously help researchers to access and share information. It is, however, becoming more and more evident that many young pharmacologists have only limited training in classical pharmacological methodologies. These long-standing and still highly relevant methods are simply not available in the electronic databases. Drug Discovery and Evaluation:Pharmacological Assays bridges this gap by comprehensively covering the pharmacological methods that have been utilized successfully for more than a hundred years as well as the latest technologies. The classical methods and the newest technologies, all in one book! The 3rd edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal, and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described. For this third edition, all existing chapters have been revised and completely updated. A large number of assays were added: we are now publishing two volumes. Sections that have been specifically enlarged include - Pharmacological assays in thrombosis and haemostasis (formerly called activity of blood constituents), - Antidiabetic activity (includes completely new chapters such as Biochemical Methods in Diabetology), - Anti-atherosclerotic activity. Audience: Pharmacologists and Pharmacists in Academia and Industry.
606   $aPharmacology
606   $aPharmacy
606   $aBiochemistry
606   $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007
606   $aPharmacy$3https://scigraph.springernature.com/ontologies/product-market-codes/F00008
606   $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005
615  0$aPharmacology.
615  0$aPharmacy.
615  0$aBiochemistry.
615 14$aPharmacology/Toxicology.
615 24$aPharmacy.
615 24$aBiochemistry, general.
676   $a615
702   $aHock$b Franz J$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910349295803321
996   $aDrug discovery and evaluation$9512478
997   $aUNINA