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101 0 $aeng
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181   $ctxt$2rdacontent
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200 10$aFc Mediated Activity of Antibodies$b[electronic resource] $eStructural and Functional Diversity /$fedited by Jeffrey V. Ravetch, Falk Nimmerjahn
205   $a1st ed. 2019.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019.
215   $a1 online resource (VII, 150 p. 14 illus., 12 illus. in color.) 
225 1 $aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v423
311   $a3-030-31052-3 
327   $aIgG Fc receptors: evolutionary considerations -- Role of FcgRs in Antibody Based Cancer Therapy -- Anti-inflammatory Activity of IgG-Fc -- IgG Fc glycosylation in human immunity -- IgE Glycosylation in Health and Disease -- Immune Complex Vaccination -- Fc receptors in anti-microbial protection.
330   $aThis volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.
410  0$aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v423
606   $aImmunology
606   $aCancer research
606   $aInfectious diseases
606   $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aInfectious Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33096
615  0$aImmunology.
615  0$aCancer research.
615  0$aInfectious diseases.
615 14$aImmunology.
615 24$aCancer Research.
615 24$aInfectious Diseases.
676   $a616.079
702   $aRavetch$b Jeffrey V$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aNimmerjahn$b Falk$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910349284103321
996   $aFc Mediated Activity of Antibodies$91918769
997   $aUNINA