LEADER 02015nam 2200469z- 450 001 9910346959103321 005 20210211 010 $a1000073428 035 $a(CKB)4920000000100931 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/55088 035 $a(oapen)doab55088 035 $a(EXLCZ)994920000000100931 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aObjective Tyre Development : Definition and Analysis of Tyre Characteristics and Quantification of their Conflicts 210 $cKIT Scientific Publishing$d2017 215 $a1 online resource (XV, 269 p. p.) 225 1 $aKarlsruher Schriftenreihe Fahrzeugsystemtechnik / Institut für Fahrzeugsystemtechnik 311 08$a3-7315-0713-7 330 $aThe present work focuses on tyres for passenger cars, especially on its influence on power loss, lateral dynamics, ride comfort and interior noise. The objective of the work is the quantification of conflicts between four selected requirements considering the physical constraints given by the tyre. The method proposed in the present book is based on a set of functional tyre characteristics, a physical tyre model and a procedure for identifying and quantifying the conflicts. 517 $aObjective Tyre Development 606 $aTechnology: general issues$2bicssc 610 $aacoustics 610 $aAkustik 610 $aGrundauslegung 610 $ainfluence 610 $aobjective 610 $aObjektiv 610 $aReifen 610 $arolling resistance 610 $aRollwiderstand 610 $aTyres 615 7$aTechnology: general issues 700 $aPeckelsen$b Ulrico$4auth$01278062 906 $aBOOK 912 $a9910346959103321 996 $aObjective Tyre Development : Definition and Analysis of Tyre Characteristics and Quantification of their Conflicts$93012498 997 $aUNINA LEADER 04529nam 2201273z- 450 001 9910557545503321 005 20220111 035 $a(CKB)5400000000044152 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76883 035 $a(oapen)doab76883 035 $a(EXLCZ)995400000000044152 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aLysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (301 p.) 311 08$a3-0365-1967-X 311 08$a3-0365-1966-1 330 $aLysosomal storage disorders are a heterogenoeus group of rare genetic conditions affecting worldwide population and often exhibiting severe clinical manifestations. During the last two decades, the joined collaboration between scientists and clinicians has allowed to offer valuable therapeutic options to affected patients. Therefore, the tight connection between basic science and clinical medicine represents the gold standard approach to these disorders. In this context, the present book collects a piece of current scientific advances in the knowledge of disease pathogenesis and in the development of novel diagnostic and therapeutic strategies for some of these diseases. Altogether, these articles define and recapitulate which essential steps are required during the clinical management of a rare inherited disorder and describe forthcoming advances and a breakthrough in the field of lysosomal diseases. 517 $aLysosomal Storage Disorders 606 $aMedicine$2bicssc 610 $aA4GALT 610 $aalpha-galactosidase A 610 $aanimal models 610 $aastrogliosis 610 $aautophagy 610 $aaxon guidance 610 $abiomarkers 610 $abone involvement 610 $acathepsin D 610 $achloroquine 610 $aclathrin 610 $aDkk1 610 $adried blood spot 610 $aendocytic pathways 610 $aendocytosis 610 $aenzyme replacement therapy 610 $aexosomes 610 $aexperimental therapies 610 $aFabry disease 610 $aGAA biomarker 610 $aGaucher disease 610 $aGaucher Disease 610 $agene therapy 610 $agene therapy. 610 $aGLA gene 610 $aglobotriaosyl-sphingosine (lysoGb3) 610 $aglobotriaosylceramide (Gb3) 610 $aglobotriaosylsphingosine 610 $aglycogen 610 $ahematopoietic stem cell transplantations 610 $aHurler syndrome 610 $aIGF2R/M6P 610 $aiPSC 610 $aKrabbe disease 610 $alyso-Gb3 610 $alysosomal diseases 610 $alysosomal storage disorder 610 $alysosomal storage disorders 610 $alysosomal targeting 610 $alysosomal ?-glucosidase 610 $alysosome 610 $alysosomes 610 $aMIP-1? 610 $amucolipidosis II 610 $amucopolysaccharidosis IIIB 610 $amucopolysaccharidosis type I 610 $amuscle 610 $aNAGLU 610 $aneurodegenerative disease 610 $aneuronal circuit 610 $aneuronopathy 610 $anewborn screening 610 $aOsteoimmunology 610 $aOsteopontin 610 $aParkinson disease 610 $apharmacological chaperone therapy 610 $apharmacological chaperones 610 $aPompe disease 610 $aprecision medicine 610 $apsychosine 610 $aquantitative proteomics 610 $aRANK/RANKL 610 $arhGAA 610 $asatellite cells 610 $asecond tier test 610 $asortilin 610 $asubstrate reduction therapy 610 $atandem mass spectrometry 610 $aTGF-beta 610 $aTwitcher mouse 610 $avariant interpretation 610 $aviral vectors 610 $avisual cortex 610 $avisual system 610 $aWnt/?-catenin 610 $aWnt3a 610 $a?-galactosidase A 615 7$aMedicine 700 $aMoro$b Enrico$4edt$01312709 702 $aMoro$b Enrico$4oth 906 $aBOOK 912 $a9910557545503321 996 $aLysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches$93030941 997 $aUNINA