LEADER 03557nam 2200721z- 450 001 9910346880103321 005 20231214132826.0 010 $a3-03921-091-2 035 $a(CKB)4920000000101719 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54614 035 $a(EXLCZ)994920000000101719 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNew research in obsessive-compulsive disorder and major depression /$fspecial issue editors, Bruno Aouizerate and Emmanuel Haffen 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (102 p.) 311 $a3-03921-090-4 330 $aMajor depression and obsessive?compulsive disorder (OCD) are now recognized among the most frequent psychiatric disorders, affecting 16?17% and 2?3% of the general population, respectively. They are commonly characterized by: i) a high level of psychiatric and somatic comorbidities; ii) a recurrence or chronic profile; and iii) a negative impact on daily functions, thereby leading to a profound impairment of quality of life. Despite significant advances in pharmacological and psychological therapies over the last decades, unsuccessful responses to standard treatment strategies are classically observed in approximately 20?30% of cases. Therefore, there is a significant need for improving the pathophysiological knowledge through a better identification of environmental, clinical, psychological, genetic, anatomical, and biological determinants, specifically implied in the development, the phenotypic expression, and the relapsing course and/or contributing to the therapeutic failure in major depression and OCD. We are convinced that this research approach is particularly relevant providing critical support for the promotion of innovative treatment alternatives potentially useful for the management of resistant forms of major depression and OCD. 606 $aObsessive-compulsive disorder 606 $aDepression, Mental 610 $ai-health 610 $aolfaction 610 $apsychiatry 610 $aobsession 610 $aobsessive-compulsive disorder 610 $atranscranial direct current stimulation 610 $aecological momentary assessment 610 $aStreptococcus pyogenes 610 $acytokines 610 $aimmunology 610 $acompulsion 610 $acognition 610 $anosography 610 $apediatric autoimmune neuropsychological disorders associated with streptococcal infection (PANDAS) 610 $asymptoms networks 610 $abrain stimulation 610 $aneuromodulation 610 $aOCD 610 $am-health 610 $acategorizations 610 $aecological momentary intervention 610 $afictional case study 610 $apediatric acute-onset neuropsychiatric syndrome (PANS) 610 $aToxoplasma gondii 610 $atDCS 610 $atherapeutic tool 610 $adepression 610 $amarkers 610 $aquality of life 610 $aTourette syndrome 615 0$aObsessive-compulsive disorder. 615 0$aDepression, Mental. 676 $a616.85/227 702 $aAouizerate$b Bruno 702 $aHaffen$b Emmanuel 906 $aBOOK 912 $a9910346880103321 996 $aNew Research in Obsessive-Compulsive Disorder and Major Depression$93031930 997 $aUNINA