LEADER 02661nam 22004453a 450 001 9910346880103321 005 20250203235431.0 010 $a9783039210916 010 $a3039210912 024 8 $a10.3390/books978-3-03921-091-6 035 $a(CKB)4920000000101719 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54614 035 $a(ScCtBLL)83ce5abe-46d0-4a03-8db4-f4a18962f23d 035 $a(OCoLC)1118516387 035 $a(EXLCZ)994920000000101719 100 $a20250203i20192019 uu 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNew Research in Obsessive-Compulsive Disorder and Major Depression$fEmmanuel Haffen, Bruno Aouizerate 210 1$aBasel, Switzerland :$cMDPI,$d2019. 215 $a1 electronic resource (102 p.) 311 08$a9783039210909 311 08$a3039210904 330 $aMajor depression and obsessive-compulsive disorder (OCD) are now recognized among the most frequent psychiatric disorders, affecting 16-17% and 2-3% of the general population, respectively. They are commonly characterized by: i) a high level of psychiatric and somatic comorbidities; ii) a recurrence or chronic profile; and iii) a negative impact on daily functions, thereby leading to a profound impairment of quality of life. Despite significant advances in pharmacological and psychological therapies over the last decades, unsuccessful responses to standard treatment strategies are classically observed in approximately 20-30% of cases. Therefore, there is a significant need for improving the pathophysiological knowledge through a better identification of environmental, clinical, psychological, genetic, anatomical, and biological determinants, specifically implied in the development, the phenotypic expression, and the relapsing course and/or contributing to the therapeutic failure in major depression and OCD. We are convinced that this research approach is particularly relevant providing critical support for the promotion of innovative treatment alternatives potentially useful for the management of resistant forms of major depression and OCD. 606 $aObsessive-compulsive disorder 606 $aDepression, Mental 615 0$aObsessive-compulsive disorder. 615 0$aDepression, Mental. 676 $a616.85/227 700 $aHaffen$b Emmanuel$01786252 702 $aAouizerate$b Bruno 801 0$bScCtBLL 801 1$bScCtBLL 906 $aBOOK 912 $a9910346880103321 996 $aNew Research in Obsessive-Compulsive Disorder and Major Depression$94317683 997 $aUNINA