LEADER 06256nam 2201921z- 450 001 9910346858503321 005 20240429223036.0 035 $a(CKB)4920000000095082 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40775 035 $a(EXLCZ)994920000000095082 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAMP-Activated Protein Kinase Signalling 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (452 p.) 311 $a3-03897-662-8 330 $aStarting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included. 610 $aHDACs 610 $atranscription 610 $aepigenetics 610 $aspermatozoa 610 $apar complex 610 $aA769662 610 $aMDCK 610 $askeletal muscle 610 $aAID 610 $aphosphorylation 610 $aenergy metabolism 610 $amonocytes 610 $aautophagy 610 $aCML 610 $aliver 610 $ahindlimb suspension 610 $apregnancy 610 $apreeclampsia 610 $agestational diabetes mellitus 610 $aCaMKK2 610 $aassisted reproduction techniques 610 $anutrient-sensing signals 610 $asonic hedgehog 610 $aprotein acetylation 610 $aglycogen storage disease 610 $aAMPK 610 $aadenosine monophosphate-activated protein kinase 610 $aAICAR 610 $aindirect calorimetry 610 $aIL-1? 610 $aMyHC I(?) 610 $aHDAC4/5 610 $aendothelial cells 610 $ainfection 610 $ahepatocyte 610 $ap70S6K 610 $alipid metabolism 610 $ahost defense 610 $aexercise 610 $akidney disease 610 $aheat shock protein 610 $a?RIM 610 $amycobacteria 610 $aactivation loop 610 $adevelopmental origins of health and disease (DOHaD) 610 $aCREB 610 $aTAK1 610 $ametabolic-inflammation 610 $aphenylephrine 610 $aAMP-activated protein kinase (AMPK) 610 $aKATs 610 $a2-methoxyestradiol 610 $aDNA methylation 610 $aNLRP3 610 $apump 610 $a?-linker 610 $asteatosis 610 $aAMPK kinase 610 $astress 610 $aendothelial nitric-oxide synthase 610 $avasodilation 610 $aadherent junctions 610 $aepithelial cells 610 $aglycogen 610 $aAkt 610 $asynaptic activation 610 $acellular energy sensing 610 $aglucose uptake 610 $atransporter 610 $aco-expression 610 $aatrophy 610 $anutrigenomics 610 $amotility 610 $avasoconstriction 610 $afatty acid oxidation 610 $aoxidative stress 610 $aAS160 610 $amembrane 610 $ahistone modification 610 $asirtuin 1 (SIRT1) 610 $achromatin remodeling 610 $ainsulin signalling 610 $adietary fatty acids 610 $aULK 610 $aCMML 610 $aadaptive thermogenesis 610 $amTOR 610 $aMDS 610 $amechanical unloading 610 $aAML 610 $aendothelial function 610 $amedulloblastoma 610 $aPKA 610 $aadipose tissue 610 $aNAD+ 610 $amembranes 610 $anutrition 610 $aZO-1 610 $aTBC1D4 610 $aadipocyte 610 $asoluble Adenylyl cyclase 610 $ametabolism 610 $arenin-angiotensin system 610 $aenergy utilization 610 $aproteasome 610 $adifferentiation 610 $asignaling 610 $aperoxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?) 610 $ahypertrophy 610 $aAMP-activated protein kinase 610 $ametabolic disease 610 $aLKB1 610 $asoleus muscle 610 $amacrophages 610 $aImmediate early genes 610 $aCBS 610 $abenign 610 $amotor endplate remodeling 610 $aionomycin 610 $anectin-afadin 610 $atight junctions 610 $aresveratrol 610 $aprotein kinase B 610 $aregrowth 610 $amitochondria 610 $aprotein synthesis 610 $aenergy deficiency 610 $acatechol-O-methyltransferase 610 $afiber-type 610 $amicroarrays 610 $acarrier 610 $aacetyl-CoA 610 $ahypertension 610 $a3T3-L1 610 $ahypothalamus 610 $afood intake 700 $aNeumann$b Dietbert$4auth$01277609 702 $aViollet$b Benoit$4auth 906 $aBOOK 912 $a9910346858503321 996 $aAMP-Activated Protein Kinase Signalling$93011715 997 $aUNINA