LEADER 03071nam 2200565z- 450 001 9910346858303321 005 20240125143506.0 010 $a3-03897-534-6 035 $a(CKB)4920000000095084 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40972 035 $a(EXLCZ)994920000000095084 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAntioxidants and Second Messengers of Free Radicals 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (194 p.) 311 $a3-03897-533-8 330 $aThe history of science can teach modern men that our understanding of life is to a great extent based on the accuracy of the analytical methods that we use and, on our readiness to oppose dogmatic opinions, which are based on outdated methods and black/white approaches to the major questions raised by mankind in the past. The recent decades have brought a lot of new insights into the fundamentals of the active principles of reactive oxygen species that are necessary for living cells, but which also cause dangerous pathophysiological processes. Accordingly, although they were previously considered to be the most undesired toxic compounds generated as the final products of the oxidative degradation of lipids, reactive aldehydes are now considered to play important roles both in health and in major diseases. Represented mostly by 4-hydroxynonenal (HNE), a substance discovered only fifty years ago, reactive aldehydes are the focus of research not only because of their toxicity but also because of their positive effects regulating the most important metabolic processes such as growth of living cells or the death of cells. Better understanding the interactions between reactive aldehydes and natural or synthetic antioxidant substances might eventually help us to better monitor, prevent and control modern diseases, thus building pillars for the development of the modern, multidisciplinary life sciences and integrative medicine of the 21st century. 610 $afree radicals 610 $alipids 610 $acell-based ELISA 610 $areactive aldehydes 610 $aantioxidants 610 $afertility 610 $areactive oxygen species ROS 610 $ahuman diseases 610 $alipid peroxidation 610 $a4-hydroxynonenal 610 $a1 610 $a4-Dihydropyridine Derivatives 610 $aomics 610 $apathophysiology 610 $agrowth control 610 $acannabinoids 610 $aplant extract 610 $amass spectrometry 610 $acell cultures 610 $acancer 610 $aaging 610 $aoxidative stress 610 $aimmunochemistry 700 $aNeven Zarkovic (Ed.)$4auth$01279678 906 $aBOOK 912 $a9910346858303321 996 $aAntioxidants and Second Messengers of Free Radicals$93015836 997 $aUNINA