LEADER 03617nam 2200841z- 450 001 9910346850303321 005 20231214133638.0 010 $a3-03897-985-6 035 $a(CKB)4920000000095164 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42575 035 $a(EXLCZ)994920000000095164 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCadmium Sources and Toxicity 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (130 p.) 311 $a3-03897-984-8 330 $aCadmium (Cd) is an environmental toxicant of continuing public health concern worldwide, because total diet studies have shown that Cd is present in virtually all foodstuffs. Consequently, foods that are frequently consumed in large quantities, such as rice, potatoes, wheat, leafy salad vegetables, and other cereal crops, are the most significant dietary Cd sources. Moreover, Cd has chemical propensities that confer the potential to interfere with the physiological functions of calcium and zinc. Evidence of a wide range of diverse, toxic effects of Cd is increasingly apparent. In this collection, environmental Cd exposure is linked to an increased risk of chronic kidney disease that is known to be a cause of morbidity and mortality worldwide. Cd is also implicated in an early onset of menarche and deaths from cancer, especially in the uterus, kidney, and urinary tract. Moreover, Cd-induced kidney injury is replicated in Sprague Dawley rats, as is Cd-induced periodontal disease. Experimental studies suggest that the development of kidneys in fetuses and the function of insulin-producing cells may be adversely affected by Cd and that metformin, an anti-diabetic drug, is ineffective in Cd-intoxicated Wistar rats. 610 $amicroRNAs 610 $aembryonic kidneys 610 $aexposure assessment 610 $aimage analysis 610 $aperiodontal disease 610 $amenopause 610 $anephrotoxicity 610 $aurine protein 610 $amitochondrial morphology 610 $afemale 610 $aalveolar bone 610 $apopulation health 610 $aglomerular filtration rate 610 $athreshold limit 610 $abiomarkers 610 $atoxicity threshold limit 610 $aosteotoxicity 610 $aintrauterine exposure 610 $ametabolic syndrome 610 $adietary cadmium 610 $aperiodontitis 610 $acadmium toxicity 610 $ametabolic disruptor 610 $acadmium 610 $aurine cadmium 610 $achronic kidney disease 610 $aN-acetyl-?-d-glucosaminidase 610 $aestimated glomerular filtration rate 610 $aone health 610 $aclinical kidney function measure 610 $a?2-microglobulin 610 $acause of death 610 $afollow-up study 610 $amenarche 610 $aHIF-1 610 $abioenergetics 610 $asub-lethal exposure 610 $ametformin 610 $atoxicological mechanism 610 $atubular dysfunction 610 $amitochondrial network 610 $aenvironmental pollution 610 $amortality 610 $abody burden indicator 610 $acancer 610 $ahypertension 700 $aSatarug$b Soisungwan$4auth$01302837 906 $aBOOK 912 $a9910346850303321 996 $aCadmium Sources and Toxicity$93026676 997 $aUNINA