LEADER 02509nam 2200373z- 450 001 9910346846003321 005 20231214133654.0 010 $a3-03897-587-7 035 $a(CKB)4920000000095180 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/62306 035 $a(EXLCZ)994920000000095180 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aVitamin D and Human Health 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (306 p.) 311 $a3-03897-586-9 330 $aOver the past decades, researchers have gathered data demonstrating that vitamin D and its metabolites possess activities far beyond the classic regulation of calcium?phosphate homeostasis. It is now well established that vitamin D is essential for the proper functioning of the musculoskeletal, cardiovascular, nervous, and immune systems. Furthermore, vitamin D and its analogs were shown to regulate proliferation and differentiation of keratinocyte, immune cells, and numerous cancer-derived cells, both in vivo and in vitro. On the other hand, population base studies have provided evidence that global vitamin D deficiency is correlated with the occurrence and aggravation of symptoms of skeletal, cardiovascular autoimmune, and skin disease; infections; metabolic and cognitive disorders; multiple types of cancers; as well as overall mortality. This Special Issue of International Journal of Molecular Sciences, entitled ?Vitamin D and Human Health?, summarizes recent advances in our understanding of pleiotropic activity of vitamin D with a focus on its protective role against cancer, hypertension, viral infections, and neurological diseases, as well as its impact on the immune system and mitochondria. Furthermore, eight research papers provide new insight into vitamin D research and highlight new directions and targets in the prevention and treatment of human diseases. 610 $aVitamin D 610 $asupplementation 610 $aextra-skeletal effects 610 $aanalogs of vitamin D 610 $atherapy and prevention 610 $avitamin D deficiency 610 $avitamin D activity and metabolism 700 $aSimon Spedding (Ed.)$4auth$01302836 906 $aBOOK 912 $a9910346846003321 996 $aVitamin D and Human Health$93026674 997 $aUNINA