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024 8 $a10.3390/books978-3-03897-462-8
035   $a(CKB)4920000000095248
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/56800
035   $a(ScCtBLL)e5c1b94c-6a34-4e1c-8bbc-699fc8c61114
035   $a(OCoLC)1163845629
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100   $a20250203i20192019  uu 
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aPPARs in Cellular and Whole Body Energy Metabolism$fRachel Tee, Walter Wahli
210   $cMDPI - Multidisciplinary Digital Publishing Institute$d2019
210  1$aBasel, Switzerland :$cMDPI,$d2019.
215   $a1 electronic resource (582 p.)
311 08$a9783038974611 
311 08$a3038974617 
330   $aAt no other time in its history has humankind been as concerned about good health. Lifestyle habits are promoted as indispensable allies for the daily prevention against so-called metabolic diseases. Paradoxically, the world has never been so obese, while the beauty canons have never been so skinny! However, there is more to energy balance than alterations in body weight. In the 1990s, it was found that fatty acids not only function as fuel molecules only, but also serve as signaling molecules. They bind nuclear hormone receptors, the Peroxisome Proliferator-Activated Receptors, commonly referred to by the acronym PPARs. PPARs are transcription factors that directly control the expression of genes of metabolism, thereby impacting a multitude of pathways crucial for whole body physiology. PPARs are also activated by synthetic agonists, which are drugs used for lowering triglycerides and blood sugar. This book features articles that address tools for the identification of novel PPAR ligands, as well as the roles of the receptors in several organs, such as the brain, heart, liver, adipose tissue, gut, and muscle. As such, this book documents the multifaceted roles of these nuclear receptors that continue to attract significant attention, not least because of their still not fully realized potential to treat several health conditions.
606   $aGenetics (non-medical)$2bicssc
610   $aLigand identification
610   $aPeroxisome Proliferator-Activated Receptors (PPARs)
610   $aEnergy homeostasis
610   $aMetabolic diseases
610   $aMetabolic regulations
610   $aTumor development
615  7$aGenetics (non-medical)
700   $aTee$b Rachel$01787374
702   $aWahli$b Walter
801  0$bScCtBLL
801  1$bScCtBLL
906   $aBOOK
912   $a9910346839203321
996   $aPPARs in Cellular and Whole Body Energy Metabolism$94320773
997   $aUNINA