LEADER 02680nam 2200445z- 450 001 9910346780503321 005 20231214141120.0 010 $a1-000-04687-7 035 $a(CKB)4920000000100718 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/51179 035 $a(EXLCZ)994920000000100718 100 $a20202102d2015 |y 0 101 0 $ager 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aKonzeption und prototypische Fertigung einer nicht-invasiven mikrofluidischen Plattform für die Elektrophysiologie (NIMEP) zur Zellenanalyse 210 $cKIT Scientific Publishing$d2015 215 $a1 electronic resource (XVII, 171 p. p.) 225 1 $aSchriften des Instituts für Mikrostrukturtechnik am Karlsruher Institut für Technologie / Hrsg.: Institut für Mikrostrukturtechnik 311 $a3-7315-0378-6 330 $aThe most commonly used measurement technique for electrophysiology is the patch clamp technique. While this measurement technique allows the precise investigation of the communication taking place through ion channels, it has some undesirable drawbacks such as the local destruction of the plasma membrane, a low success rate and an elaborate experimental procedure. To avoid these drawbacks, in this work a new non-invasive microfluidic platform for electrophysiological research (NIMEP) was developed with regard to the activity of ion channels. This novel approach is based on the non-invasive measurement of the total current through the cell membrane and provides a possibility for an automated investigation of the individual cells. In addition, the investigated cell can be used for other applications, since the cell remains in an intact state before and after the test. 517 $aKonzeption und prototypische Fertigung einer nicht-invasiven mikrofluidischen Plattform für die Elektrophysiologie 517 $aKonzeption und prototypische Fertigung einer nicht-invasiven mikrofluidischen Plattform für die Elektrophysiologie 610 $aNicht-invasiv 610 $aMikrofluidik 610 $aNon-invasive 610 $aPatch clamp technique 610 $aIonenkanal 610 $aElectrophysiology 610 $aElektrophysiologie 610 $aIon channel 610 $aPatch-Clamp-Technik 610 $aMicrofluidics 700 $aKim$b Seoung-Eun$4auth$01305276 906 $aBOOK 912 $a9910346780503321 996 $aKonzeption und prototypische Fertigung einer nicht-invasiven mikrofluidischen Plattform für die Elektrophysiologie (NIMEP) zur Zellenanalyse$93027827 997 $aUNINA