LEADER 00904cam0-2200313---450- 001 990008602540403321 005 20160419100635.0 010 $a90-04-08848-2 035 $a000860254 035 $aFED01000860254 035 $a(Aleph)000860254FED01 035 $a000860254 100 $a20080117d1988----km-y0itay50------ba 101 0 $aeng 102 $aNL 105 $a--------001yy 200 1 $aA. E. Housman at University College, London$ethe election of 1892$fby P. G. Naiditch 210 $aLeiden$cBrill$d1988 215 $aXXI, 261 p.$d24 cm 610 0 $aHousman, Alfred Edward 676 $a821.912$v22$zita 700 1$aNaiditch,$bPaul G.$0305775 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990008602540403321 952 $a821.912 HOUS/S 1$bBibl.9498$fFLFBC 959 $aFLFBC 996 $aA. E. Housman at University College, London$9712381 997 $aUNINA LEADER 01349nam--2200421---450- 001 990000382710203316 005 20060118133929.0 010 $a1898519021 035 $a0038271 035 $aUSA010038271 035 $a(ALEPH)000038271USA01 035 $a0038271 100 $a20010329d1994----km-y0itay0103----ba 101 $aeng 102 $aGB 105 $a||||||||001yy 200 1 $aArt for the people$eculture inthe slums of late Victorian Britain$fedited by Giles Waterfield 210 $aLondon$cDulwitch picture Gallery$d1994 215 $a104 p.$cill.$d24 cm 300 $aCatalogo della mostra tenuta alla Dulwich picture Gallery nel 1994 410 $12001 606 0 $aPittura$xEsposizioni$yGran Bretagna$zSec.19. 606 0 $aPittura$yLondra$xEsposizioni 606 0 $aSouth London Gallery$xStoria 606 0 $aArte e società$yLondra$xStoria$zSec.19.$xEsposizioni 676 $a759.05 702 1$aWATERFIELD,$bGiles 801 0$aIT$bsalbc$gISBD 912 $a990000382710203316 951 $aXII.2.C. 603(VII E 425)$b134983 LM$cVII E 959 $aBK 969 $aUMA 979 $aPATTY$b90$c20010329$lUSA01$h1624 979 $c20020403$lUSA01$h1646 979 $aPATRY$b90$c20040406$lUSA01$h1626 979 $aCOPAT6$b90$c20060118$lUSA01$h1339 996 $aArt for the people$9875470 997 $aUNISA LEADER 03223nam 2200421z- 450 001 9910346758703321 005 20210211 035 $a(CKB)4920000000094127 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53231 035 $a(oapen)doab53231 035 $a(EXLCZ)994920000000094127 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMetabolism and Immune Tolerance 210 $cFrontiers Media SA$d2019 215 $a1 online resource (116 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-725-7 330 $aHistorically the study of the immune system and metabolism have been two very separate fields. In recent years, a growing literature has emerged illustrating how the multiple processes of cellular metabolism are intricately linked to several aspects of immune function and development. This Research Topic covers recent progress in the field now known as "Immunometabolism" and the role of metabolism in immune tolerance. Immune tolerance is operationally defined as a state where a host's immune system is balanced such that although self-reactive lymphocytes are present, they are kept in check by immune regulation. Perturbations to this homeostasis may result in self-reactive lymphocytes gaining the upper hand and mediating auto-immune disease. Maintenance of immune tolerance involves a large cast of different cell types including effector T cells, regulatory T cells, B cells, stromal cells, dendritic cells and macrophages. Intracellular pathways and individual enzymes of metabolism have been shown to be harnessed by cells of both the adaptive and innate immune system to allow particular immune functions to be achieved. Examples include metabolic enzymes serving 'moonlighting' functions in mRNA translation, gene splicing, and kinase activation. Other examples include the requirement for de novo fatty acid synthesis for differentiation into Th17 effectors and CD8 memory T cells or products of the TCA cycle promoting pro-inflammatory cytokine production. Likewise, the availability of extracellular metabolic substrates has a large impact on the maintenance of local immune tolerance. For example, there are different requirements for glucose, glutamine and fatty acids for effector versus regulatory T cell development. Also tolerogenic dendritic cells mediate lowering of extracellular essential amino acids by their enhanced catabolism, promoting the induction of regulatory T cells. The purpose of this Research Topic is to provide an update on the current understanding of the multiple roles for metabolism in regulating the immune system. 606 $aMedicine and Nursing$2bicssc 610 $aB cell 610 $aGvHD 610 $aImmune Tolerance 610 $amacrophage 610 $aMetabolism 610 $aT cell 610 $aTransplantation 615 7$aMedicine and Nursing 700 $aClaudio Mauro$4auth$01287679 702 $aDuncan Howie$4auth 906 $aBOOK 912 $a9910346758703321 996 $aMetabolism and Immune Tolerance$93020288 997 $aUNINA