LEADER 01246nam a22002891i 4500 001 991000655089707536 005 20021127143911.0 008 021022s1983 it |||||||||||||||||ita 035 $ab1203597x-39ule_inst 035 $aARCHE-012577$9ExL 040 $aDip.to Filologia Ling. e Lett.$bita$cA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l. 245 03$aIl segno dei tre :$bHolmes, Dupin, Peirce /$ca cura di Umberto Eco e Thomas A. Sebeok 260 $aMilano :$bBompiani,$c1983 300 $a309 p. ;$c22 cm 490 0 $aStudi Bompiani.$pIl campo semiotico 650 4$aLetteratura poliziesca$xStudio semiotico 650 4$aSemiotica 700 1 $aEco, Umberto 700 1 $aSebeok, Thomas Albert$d<1920- > 907 $a.b1203597x$b28-04-17$c01-04-03 912 $a991000655089707536 945 $aLE008 FL.M. (IN) C 143$g1$i2008000183646$lle008$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i12327372$z01-04-03 945 $aLE008$g2$lle008$nDA ELIMINARE$on$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i12327384$z01-04-03 945 $aLE008 Cr M III 50$g3$i2008000238391$lle008$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i12327396$z01-04-03 996 $aSegno dei tre$9141624 997 $aUNISALENTO 998 $ale008$b01-04-03$cm$da $e-$fita$git $h3$i3 LEADER 02764nam 2200421z- 450 001 9910346757603321 005 20210211 035 $a(CKB)4920000000094138 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/56243 035 $a(oapen)doab56243 035 $a(EXLCZ)994920000000094138 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPhysiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor 210 $cFrontiers Media SA$d2018 215 $a1 online resource (189 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-512-2 330 $aCalcium is vital for human physiology; it mediates multiple signaling cascades, critical for cell survival, differentiation, or death both as first and as second messenger. The role of calcium as first messenger is mediated by the G-protein coupled receptor, the extracellular calcium-sensing receptor (CaSR). The CaSR is a multifaceted molecule that senses changes in the concentration of a wide variety of environmental factors including di- and trivalent cations, amino acids, polyamines, and pH. In calcitropic tissues with obvious roles in calcium homeostasis such as parathyroid, kidney, and bone it regulates circulating calcium concentrations. The germline mutations of the CaSR cause parathyroid disorders demonstrating the importance of the CaSR for the maintenance of serum calcium homeostasis. The CaSR has an important role also in a range of non-calcitropic tissues, such as the intestine, lungs, central and peripheral nervous system, breast, skin and reproductive system, where it regulates molecular and cellular processes such as gene expression, proliferation, differentiation and apoptosis; as well as regulating hormone secretion and lactation. This Research Topic is an overview of the CaSR and its molecular signaling properties together with the various organ systems where it plays an important role. The articles highlight the current knowledge regarding many aspects of the calcitropic and non-calcitropic physiology and pathophysiology of the CaSR. 606 $aPhysiology$2bicssc 610 $aAlzheimer 610 $acancer 610 $acrystal structure 610 $aG protein-coupled receptor (GPCR) 610 $ametastasis 610 $aparathyroid hormone (PTH) 610 $aproliferation and differentiation 610 $avitamin D 615 7$aPhysiology 700 $aEnikö Kallay$4auth$01305950 906 $aBOOK 912 $a9910346757603321 996 $aPhysiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor$93028055 997 $aUNINA