LEADER 02574nam  2200457z- 450 
001 9910346757403321
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035   $a(CKB)4920000000094140
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/41029
035   $a(oapen)doab41029
035   $a(EXLCZ)994920000000094140
100   $a20202102d2018      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aApoptotic Cell Clearance in Health and Disease
210   $cFrontiers Media SA$d2018
215   $a1 online resource (294 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-688-9 
330   $aClearance of apoptotic cells is essential for proper development, homeostasis and termination of immune responses in multicellular organisms. Thus, cellular and molecular players taking part in the sequential events of this process are of great interest. Research in the last 20 years has indicated that specific ligands and receptors take part in the attraction of immune cells toward apoptotic targets and in the interactions between apoptotic cells and professional as well as non-professional phagocytes that engulf them. Moreover, phagocytosis of apoptotic cells (efferocytosis) leads to significant phenotypic changes in the engulfing cells suggesting that it is a major fate-determining event for phagocytes. Particularly, efferocytosis has an important impact on the inflammation-resolution axis as well as embryonic development and tissue morphogenesis. Deficiencies in these processes can result in health threats, such as autoimmunity, atherosclerosis, bone loss, obesity, infertility, neurodegeneration, fibrosis and cancer. This eBook brings together 24 original research and review manuscripts that cover various aspects of apoptotic cell removal during normal development and homeostasis as well as in tumorigenesis and regenerative processes following injury.
606   $aMedicine$2bicssc
610   $aApoptosis
610   $adevelopment
610   $aEfferocytosis
610   $aHomeostasis
610   $aimmune-regulation
610   $aneurodegeneration
610   $aPhagocytes
610   $areceptor-ligand interactions
610   $atumorigenesis
615  7$aMedicine
700   $aAmiram Ariel$4auth$01331927
702   $aKirsten Lauber$4auth
702   $aEstee Kurant$4auth
906   $aBOOK
912   $a9910346757403321
996   $aApoptotic Cell Clearance in Health and Disease$93040659
997   $aUNINA