LEADER 03219nam  2200445z- 450 
001 9910346756303321
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035   $a(CKB)4920000000094151
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/61874
035   $a(oapen)doab61874
035   $a(EXLCZ)994920000000094151
100   $a20202102d2018      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aThe Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration
210   $cFrontiers Media SA$d2018
215   $a1 online resource (174 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-410-X 
330   $aTissues and organs have, although sometimes limited, the capacity for endogenous repair, which is aimed to re-establish integrity and homeostasis. Tissue repair involves pro- and anti-inflammatory processes, new tissue formation and remodelling. Depending on the local microenvironment, tissue repair results either in scar tissue formation or in regeneration. The latter aims to recapitulate the original tissue structure and architecture with the proper functionality. Although some organisms (such as planarians) have a high regenerative capacity throughout the body, in humans this property is more restricted to a few organs and tissues. Regeneration in the adult is possible in particular through the existence of tissue-resident pools of stem/progenitor cells. In response to tissue damage, these cells are activated, they proliferate and migrate, and differentiate into mature cells. Angiogenesis and neovascularization play a crucial role in tissue repair. Besides providing with oxygen and nutrients, angiogenesis generates a vascular niche (VN) consisting of different blood-derived elements and endothelial cells surrounded by basement membrane as well as perivascular cells. The newly generated VN communicates with the local stem/progenitor cells and contributes to tissue repair. For example, platelets, macrophages, neutrophils, perivascular cells and other VN components actively participate in the repair of skin, bone, muscle, tendon, brain, spinal cord, etc. Despite these observations, the exact role of the VN in tissue repair and the underlying mechanisms are still unclear and are awaiting further evidence that, indeed, will be required for the development of regenerative therapies for the treatment of traumatic injuries as well as degenerative diseases.
517   $aVascular Niche in Tissue Repair
606   $aNeurosciences$2bicssc
610   $aAngiogenesis
610   $aBlood Vessels and Endothelial Cells
610   $aGranulocyte Colony Stimulating Factor (G-CSF)
610   $aPericytes
610   $aPlatelets and Platelets Lysate
610   $aStem and Progenitor Cells
610   $aTissue Repair and Regeneration
610   $aVascular Niche
615  7$aNeurosciences
700   $aFrancisco J. Rivera$4auth$01315252
702   $aLudwig Aigner$4auth
906   $aBOOK
912   $a9910346756303321
996   $aThe Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration$93032302
997   $aUNINA