LEADER 01192nam--2200385---450- 001 990001253880203316 005 20031111101847.0 035 $a000125388 035 $aUSA01000125388 035 $a(ALEPH)000125388USA01 035 $a000125388 100 $a20031111d1959----km-y0itay0103----ba 101 0 $aita 102 $aIT 105 $a||||||||001yy 200 1 $a<>educazione dei giovani particolarmente dotati$fRoberto Assagioli 210 $aFirenze$cEd. tip. Tipocalcografia Classica$d1959 215 $d21 cm 300 $aEstratto da: Umanità in cammino. - Vol. 4 (1959). - P. 11 410 0$12001 454 1$12001 461 1$1001-------$12001 700 $aASSAGIOLI,$bRoberto$0161082 801 0$aIT$bsalbc$gISBD 912 $a990001253880203316 951 $aVI-Misc. 44/1$b10960 L.M.$cVI-Misc. 959 $aBK 969 $aUMA 979 $aSIAV7$b10$c20031111$lUSA01$h1009 979 $aSIAV7$b10$c20031111$lUSA01$h1010 979 $aSIAV7$b10$c20031111$lUSA01$h1013 979 $aSIAV7$b10$c20031111$lUSA01$h1018 979 $aPATRY$b90$c20040406$lUSA01$h1729 996 $aEducazione dei giovani particolarmente dotati$9986710 997 $aUNISA LEADER 03219nam 2200445z- 450 001 9910346756303321 005 20210212 035 $a(CKB)4920000000094151 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/61874 035 $a(oapen)doab61874 035 $a(EXLCZ)994920000000094151 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aThe Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration 210 $cFrontiers Media SA$d2018 215 $a1 online resource (174 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-410-X 330 $aTissues and organs have, although sometimes limited, the capacity for endogenous repair, which is aimed to re-establish integrity and homeostasis. Tissue repair involves pro- and anti-inflammatory processes, new tissue formation and remodelling. Depending on the local microenvironment, tissue repair results either in scar tissue formation or in regeneration. The latter aims to recapitulate the original tissue structure and architecture with the proper functionality. Although some organisms (such as planarians) have a high regenerative capacity throughout the body, in humans this property is more restricted to a few organs and tissues. Regeneration in the adult is possible in particular through the existence of tissue-resident pools of stem/progenitor cells. In response to tissue damage, these cells are activated, they proliferate and migrate, and differentiate into mature cells. Angiogenesis and neovascularization play a crucial role in tissue repair. Besides providing with oxygen and nutrients, angiogenesis generates a vascular niche (VN) consisting of different blood-derived elements and endothelial cells surrounded by basement membrane as well as perivascular cells. The newly generated VN communicates with the local stem/progenitor cells and contributes to tissue repair. For example, platelets, macrophages, neutrophils, perivascular cells and other VN components actively participate in the repair of skin, bone, muscle, tendon, brain, spinal cord, etc. Despite these observations, the exact role of the VN in tissue repair and the underlying mechanisms are still unclear and are awaiting further evidence that, indeed, will be required for the development of regenerative therapies for the treatment of traumatic injuries as well as degenerative diseases. 517 $aVascular Niche in Tissue Repair 606 $aNeurosciences$2bicssc 610 $aAngiogenesis 610 $aBlood Vessels and Endothelial Cells 610 $aGranulocyte Colony Stimulating Factor (G-CSF) 610 $aPericytes 610 $aPlatelets and Platelets Lysate 610 $aStem and Progenitor Cells 610 $aTissue Repair and Regeneration 610 $aVascular Niche 615 7$aNeurosciences 700 $aFrancisco J. Rivera$4auth$01315252 702 $aLudwig Aigner$4auth 906 $aBOOK 912 $a9910346756303321 996 $aThe Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration$93032302 997 $aUNINA