LEADER 00822nam0-22003131i-450- 001 990007094740403321 005 20020619 010 $a0-669-02841-X 035 $a000709474 035 $aFED01000709474 035 $a(Aleph)000709474FED01 035 $a000709474 100 $a20020619d1979----km-y0itay50------ba 101 0 $aeng 102 $aUS 105 $ay-------001yy 200 1 $aHostage-taking$fRonald D. Crelinsten, Denis Szabo 210 $aLexington$cHeath$d1979 215 $aXII, 160 p.$d24 cm 225 1 $aLexington Books 700 1$aCrelinsten,$bRonald D.$0261095 701 1$aSzabo,$bDenis$0261096 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990007094740403321 952 $aX W 23$b115068$fFGBC 959 $aFGBC 996 $aHostage-taking$9704306 997 $aUNINA LEADER 02984nam 2200385z- 450 001 9910346754903321 005 20210211 035 $a(CKB)4920000000094165 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42237 035 $a(oapen)doab42237 035 $a(EXLCZ)994920000000094165 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBiology and Pathogenesis of Legionella 210 $cFrontiers Media SA$d2018 215 $a1 online resource (181 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-661-7 330 $aLegionella pneumophila was first isolated as the causative agent of a deadly infectious pneumonia at a convention of the American Legion forty years ago. Since then, Legionnaires' disease continues to be a significant public health concern. Today, our understanding of the Legionella genus, comprising environmental bacteria and opportunistic human pathogens, has dramatically increased. The study of how pathogenic Legionella interact with host cells, both protozoan and mammalian, has not only taught us about host-pathogen interactions but has revealed novel and unexpected insights into human cell biology and immunology. The capacity of pathogenic Legionella to commandeer cellular processes such as eukaryotic vesicular trafficking to establish an ER-like replicative niche, reflects the exquisite ability of this pathogen to manipulate eukaryotic cell biology in order to replicate in an intracellular compartment. This requires the specific and targeted action of a cohort of translocated bacterial effector proteins. In addition, we have learnt much about cell autonomous innate immune sensing of intracellular bacteria through the inability of L. pneumophila to avoid intracellular mammalian defense mechanisms. Now, in the age of large-scale comparative "omics", it is clear that different Legionella species utilize different cohorts of effectors to replicate inside eukaryotic cells. While we understand some of the strategies employed by L. pneumophila and L. longbeachae to replicate within eukaryotic cells, there is still much to learn about many aspects of the Legionella life cycle. This Research Topic highlights the latest findings regarding the biology of Legionella species, their interactions with eukaryotic host cells, and how the application of various technologies has increased our understanding of this important pathogen. 610 $aDot/Icm effector 610 $aHost-Pathogen Interactions 610 $aintravacuolar pathogen 610 $aLegionella 610 $aLegionnaires' Disease 700 $aMatthias Machner$4auth$01331091 702 $aHayley Newton$4auth 702 $aElizabeth Hartland$4auth 906 $aBOOK 912 $a9910346754903321 996 $aBiology and Pathogenesis of Legionella$93040119 997 $aUNINA