LEADER 02668nam  2200409z- 450 
001 9910346751503321
005 20231214133206.0
035   $a(CKB)4920000000094199
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54426
035   $a(EXLCZ)994920000000094199
100   $a20202102d2018      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aThe Neonatal Immune System: A Unique Host-Microbial Interface
210   $cFrontiers Media SA$d2018
215   $a1 electronic resource (175 p.)
225 1 $aFrontiers Research Topics
311   $a2-88945-403-7 
330   $aEmerging from the protective environment of the uterus, the newborn is exposed to a myriad of microbes, and quickly establishes a complex microbiome that shapes the infant?s biology in ways that are only now beginning to come to light. Among these exposures are a number of potential pathogens. The host responses to these pathogens in the neonatal period are unique, reflecting a developing immune system even with delivery at term. Preterm infants are delivered at a time when host defense mechanisms are even less developed and therefore face additional risk. As such, the organisms that cause disease in this period are different from the pathogens that are common in other age groups, or the disease they cause manifests in more severe fashion. Developmental alterations in both innate and adaptive immune responses in neonates have been documented among many cell types and pathways over the last several decades. Contemporary insights into the human immune system and methodologies that allow an ?omics? approach to these questions have continued to provide new information regarding the mechanisms that underlie the human neonate as an ?immunocompromised host.? This Research Topic highlights studies related to this unique host-pathogen interface. Contributions include those related to the innate or adaptive immune system of neonates, their response to microbial colonization or infection, and/or the pathogenesis of microbes causing disease in neonates.
517   $aNeonatal Immune System
610   $aInfection
610   $aNeonate
610   $aCandida
610   $aSepsis
610   $aNecrotizing enterocolitis
610   $aVaccine
610   $aImmunity
610   $aMicrobiome
700   $aJoseph M. Bliss$4auth$01324761
702   $aJames L. Wynn$4auth
906   $aBOOK
912   $a9910346751503321
996   $aThe Neonatal Immune System: A Unique Host-Microbial Interface$93036263
997   $aUNINA