LEADER 03398nam 2200457z- 450 001 9910346750703321 005 20210212 035 $a(CKB)4920000000094207 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/62678 035 $a(oapen)doab62678 035 $a(EXLCZ)994920000000094207 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aWhy Have Cortical Layers? What Is the Function of Layering? Do Neurons in Cortex Integrate Information Across Different Layers? 210 $cFrontiers Media SA$d2018 215 $a1 online resource (208 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-660-9 330 $aThis research topic was suggested by Robert Sachdev to bring together a series of articles dealing with the laminar organization of the neocortex. By convention, there are six cortical layers but this number may vary throughout the cerebral cortex of a given species or between species: many regions lack one or more layers, whereas in other regions there are more than six layers. The laminar location of cortical neurons -their cell bodies- is determined during development. However, neurons are more than their cell bodies; they also have dendrites that may span within a given layer (intralaminar neurons) or across a variety of layers (translaminar neurons). For example, layer V pyramidal neurons have dendrites that span the entire cortical depth, whereas layer III pyramidal neurons have dendrites that span across layers I to IV. Some GABAergic interneurons have dendrites located within a cortical layer (e.g., neurogliaform cells), whereas the dendrites of other interneurons span several layers (e.g., bitufted cells). For neurons having dendrites that cross laminar boundaries, one might ask, why segregate their cell bodies so carefully into lamina? Among many other obvious questions: What is the evidence for or against integration of information across laminae for neurons whose dendrites span several layers? A traditional view is that activity flows through cortical layers in a feed-forward manner, going from layer IV, to layers II and III and onwards. Another view is that cortical layers can have distinct inputs that activate them, triggering spikes. Can processing sequences be state dependent? Furthermore, different cortical layers have distinct transcriptomic profiles, neurochemical attributes, connectivity patterns, number and types of synapses and many other structural attributes. Thus, based on anatomy, or physiology or imaging: What is the function of each cortical layer? What do the different layers do? 606 $aNeurosciences$2bicssc 610 $acell types 610 $aCortical evolution 610 $aGABAergic connectivity 610 $ainsular cortex 610 $aisocortex 610 $aolfactory 610 $aperiallocortex 610 $aPyramidal neurons 610 $areceptors 610 $aReeler 615 7$aNeurosciences 700 $aJavier DeFelipe$4auth$01320444 702 $aKathleen Rockland$4auth 906 $aBOOK 912 $a9910346750703321 996 $aWhy Have Cortical Layers? What Is the Function of Layering? Do Neurons in Cortex Integrate Information Across Different Layers$93034315 997 $aUNINA