LEADER 02120nam  2200409z- 450 
001 9910346750303321
005 20210212
035   $a(CKB)4920000000094211
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/59417
035   $a(oapen)doab59417
035   $a(EXLCZ)994920000000094211
100   $a20202102d2018      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aSingle-Domain Antibodies: Biology, Engineering and Emerging Applications
210   $cFrontiers Media SA$d2018
215   $a1 online resource (338 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-432-0 
330   $aSingle-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics.
517   $aSingle-Domain Antibodies
606   $aMedicine and Nursing$2bicssc
610   $aantibody discovery
610   $aantibody engineering
610   $adiagnostic antibody
610   $asingle-domain antibody
610   $atherapeutic antibody
615  7$aMedicine and Nursing
700   $aKevin A. Henry$4auth$01279436
702   $aC. Roger MacKenzie$4auth
906   $aBOOK
912   $a9910346750303321
996   $aSingle-Domain Antibodies: Biology, Engineering and Emerging Applications$93015375
997   $aUNINA