LEADER 02855nam  2200397z- 450 
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035   $a(CKB)4920000000094213
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/52877
035   $a(oapen)doab52877
035   $a(EXLCZ)994920000000094213
100   $a20202102d2018      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aMathematics for Healthcare
210   $cFrontiers Media SA$d2018
215   $a1 online resource (284 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-577-7 
330   $aIn 1996, and with extraordinary prescience, Panfilov and Holden had highlighted in their seminal book 'Computational Biology of the Heart' that biology was, potentially, the most mathematical of all sciences. Fast-forward 20 years and we have seen an explotion of applications of mathematics in not only biology, but healthcare that has already produced significant breakthroughs not imaginable more than 20 years ago. Great strides have been made in explaining through quantitative methods the underlying mechanisms of human disease, not without considerable ingenuity and effort. Biological mechanisms are bewildering: complex, ever evolving, multi-scale, variable, difficult to fully access and understand. This poses immense challenges to the computational physiology community that, nevertheless, has developed an impressive arsenal of tools and methods in a vertiginous race to combat disease with the tall order of improving human healthcare. Mechanistic models are now contending with the advent of machine learning in healthcare and the hope is that both approaches will be used synergistically since the complexity of human patophysiology and the difficulty of acquiring human datasets will require both, deductive and inductive methods. This Research Topic presents work that is currently at the frontier in computational physiology with a striking range of applications, from diabetes to graft failure and using a multitude of mathematical tools. This collection of articles represents a snapshot in a field that is moving a dizzying speed, bringing understanding of fundamental mechanism and solutions to healthcare problems experienced by healthcare systems all over the world.
606   $aPhysiology$2bicssc
610   $acomputational physiology
610   $adata-driven modelling
610   $amathematics for healthcare
610   $amechanistic modelling
610   $aprecision medicine
615  7$aPhysiology
700   $aVanessa Diaz-Zuccarini$4auth$01284069
702   $aKrasimira Tsaneva-Atanasova$4auth
906   $aBOOK
912   $a9910346750103321
996   $aMathematics for Healthcare$93019258
997   $aUNINA