LEADER 03839nam 2200433z- 450 001 9910346749503321 005 20231214133344.0 035 $a(CKB)4920000000094219 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/59061 035 $a(EXLCZ)994920000000094219 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aThe Search for Biological Active Agent(s) From Actinobacteria 210 $cFrontiers Media SA$d2018 215 $a1 electronic resource (312 p.) 225 1 $aFrontiers Research Topics 311 $a2-88945-567-X 330 $aThere is a large market demand for new drugs. The existing chronic or common ailments without cures, development of new diseases with unknown causes, and the widespread existence of antibiotic-resistant pathogens, have driven this field of research further by looking at all potential sources of natural products. To date, microbes have made a significant contribution to the health and well-being of people globally. The discoveries of useful metabolites produced by microbes have resulted in a significant proportion of pharmaceutical products in today?s market. Therefore, the investigation and identification of bioactive compound(s) producing microbes is always of great interest to researchers.

Actinobacteria are one of the most important and efficient groups of natural metabolite producers. Among the numerous genera, Streptomyces have been recognized as prolific producers of useful natural compounds, as they provide more than half of the naturally-occurring antibiotics isolated to-date and continue to emerge as the primary source of new bioactive compounds. Certainly, these potentials have attracted ample research interest and a wide range of biological activities have been subsequently screened by researchers with the utilization of different In vitro and In vivo model of experiments. Literature evidence has shown that a significant number of interesting compounds produced by Actinobacteria were exhibiting either strong anticancer or neuroprotective activity. The further in depth studies have then established the modulation of apoptotic pathway was involved in those observed bioactivities. These findings indirectly prove the biopharmaceutical potential possessed by Actinobacteria and at the same time substantiate the importance of diverse pharmaceutical evaluations on Actinobacteria. In fact, many novel compounds discovered from Actinobacteria with strong potential in clinical applications have been developed into new drugs by pharmaceutical companies. Together with the advancement in science and technology, it is predicted that there would be an expedition in discoveries of new bioactive compounds producing Actinobacteria from various sources, including soil and marine sources. In light of these current needs, and great interest in the scope of this research, this book seeks to contribute on the investigation of different biological active compound(s) producing actinobacteria which are exhibiting antimicrobial, antioxidant, neuroprotective, anticancer activities and similar. 517 $aSearch for Biological Active Agent 610 $aactinobacteria 610 $aterrestrial 610 $adrug discovery 610 $anext generation 610 $aStreptomyces 610 $amarine 610 $abioactive 700 $aLearn-Han Lee$4auth$01328926 702 $aKok-Gan Chan$4auth 702 $aBey-Hing Goh$4auth 702 $aElizabeth M. H. Wellington$4auth 702 $aJem Stach$4auth 906 $aBOOK 912 $a9910346749503321 996 $aThe Search for Biological Active Agent(s) From Actinobacteria$93039182 997 $aUNINA